VPRBP and UNG

Number of citations of the paper that reports this interaction (PMID 20870715)
26

Data Source:
BioGRID (enzymatic study)

		VPRBP	UNG
Gene Name		Vpr (HIV-1) binding protein	uracil-DNA glycosylase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm COP9 Signalosome	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding ATP Binding Histone Kinase Activity (H2A-T120 Specific)	Uracil DNA N-glycosylase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Viral Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ATM ATR HDAC1 HIST1H3A HIST3H3 KATNA1 MCM10 NF2 PRKDC RAG1 RBX1 TP53 UBE2D2 UNG	7 interactors: APP CAPN11 DDB1 PCNA RPA2 SEZ6L2 VPRBP
Entrez ID		9730	7374
HPRD ID		11674	01881
Ensembl ID			ENSG00000076248
Uniprot IDs		Q9Y4B6	E5KTA5 E5KTA6 P13051
PDB IDs			1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Response To Gamma Radiation Replicative Senescence DNA Recombination B Cell Differentiation V(D)J Recombination DNA Repair Chromosome Organization Response To Ionizing Radiation Organelle Organization DNA Damage Checkpoint Double-strand Break Repair B Cell Activation Regulation Of Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Negative Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Pre-B Cell Allelic Exclusion Cell Cycle Cellular Response To DNA Damage Stimulus Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint B Cell Lineage Commitment Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint T Cell Differentiation In Thymus Cell Aging Lymphocyte Differentiation Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cellular Response To Stress Pre-B Cell Differentiation Somitogenesis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Immature B Cell Differentiation Response To Hypoxia	Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition DNA Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Chromosome Organization DNA Metabolic Process Regulation Of Mitotic Cell Cycle Mismatch Repair Base-excision Repair Homeostatic Process Telomere Maintenance Regulation Of Cell Cycle Process Cell Competition In A Multicellular Organism Positive Regulation Of Deoxyribonuclease Activity Histone H2A-T120 Phosphorylation DNA-dependent DNA Replication DNA Repair Cellular Homeostasis Leading Strand Elongation Synaptic Growth At Neuromuscular Junction DNA Catabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation By Virus Of Viral Protein Levels In Host Cell Collateral Sprouting In Absence Of Injury Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition DNA Recombinase Assembly Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition UV-damage Excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell DNA Replication
Tagcloud ?		a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal replication restricting screen unveiling versatility vif virion	choe collided colonial communism communist cooperatives defected defection faction heath ideologies imagination instatement laborers liberation nationalization pharmaceutics politics pyongyang reeducation respite socialism socialist sok soviet stood symbolically unions usamgik
Tagcloud (Difference) ?		a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal replication restricting screen unveiling versatility vif virion	choe collided colonial communism communist cooperatives defected defection faction heath ideologies imagination instatement laborers liberation nationalization pharmaceutics politics pyongyang reeducation respite socialism socialist sok soviet stood symbolically unions usamgik
Tagcloud (Intersection) ?