UBAC1 and PLAAT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBAC1	PLAAT2
Description		UBA domain containing 1	phospholipase A and acyltransferase 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity
	Biological Process	Protein Ubiquitination Protein Maturation	Lipid Metabolic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling N-acylphosphatidylethanolamine Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Acyl chain remodelling of PE
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B	6 interacting genes: ASPH HPCAL1 NCALD UBAC1 UBQLN1 UBQLN2
Entrez ID		10422	54979
HPRD ID		12170	13670
Ensembl ID		ENSG00000130560	ENSG00000133328
Uniprot IDs		A0A140VK64 Q9BSL1	Q9NWW9
PDB IDs		2DAI	4DPZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process	Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Calcium-mediated Signaling Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Activation Of Store-operated Calcium Channel Activity Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Catabolic Process Regulation Of Calcium Ion Transport Clathrin Coat Of Trans-Golgi Network Vesicle Cortical Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagy Positive Regulation Of Calcium Ion Transport Into Cytosol Aggrephagy Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Receptor Internalization Regulation Of Metal Ion Transport Proteasome Binding Regulation Of Clathrin-dependent Endocytosis
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