UBAC1 and MGAT3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBAC1	MGAT3
Description		UBA domain containing 1	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity
	Biological Process	Protein Ubiquitination Protein Maturation	N-acetylglucosamine Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Intracellular Protein Localization Regulation Of Cell Migration Cellular Response To Oxidative Stress Amyloid-beta Metabolic Process Cognition Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Reactions specific to the hybrid N-glycan synthesis pathway
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Post bronchodilator FEV1 ( 26634245) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698)
Interacting Genes		37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B	1 interacting genes: UBAC1
Entrez ID		10422	4248
HPRD ID		12170	07058
Ensembl ID		ENSG00000130560	ENSG00000128268
Uniprot IDs		A0A140VK64 Q9BSL1	Q09327
PDB IDs		2DAI
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process	Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Protein Maturation Lipopolysaccharide Receptor Complex Migrasome Coated Vesicle Protein Import Into Mitochondrial Intermembrane Space Apolipoprotein A-I Binding Cellular Response To Unfolded Protein MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interleukin-7 Adhesion Of Symbiont To Host Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Interleukin-7 Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell High-density Lipoprotein Particle Binding Sperm Plasma Membrane Apolipoprotein Binding Negative Regulation Of Execution Phase Of Apoptosis 'de Novo' Protein Folding Cysteine-type Endopeptidase Activator Activity DNA Replication Origin Binding Proteasome Binding Positive Regulation Of Execution Phase Of Apoptosis Chaperone-mediated Protein Complex Assembly Isotype Switching Positive Regulation Of Macrophage Activation Regulation Of Response To Tumor Cell Positive Regulation Of Interferon-alpha Production Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Topologically Incorrect Protein Protein Refolding Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Protein Localization To Mitochondrion Response To Cold Biological Process Involved In Interaction With Symbiont Somatic Diversification Of Immunoglobulins B Cell Proliferation Polyubiquitin Modification-dependent Protein Binding Somatic Cell DNA Recombination Toll-like Receptor Signaling Pathway Sperm Midpiece Regulation Of Macrophage Activation B Cell Activation Involved In Immune Response
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