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PPP3CB and IRAK1
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
55
Data Source:
BioGRID
(affinity chromatography technology, pull down)
PPP3CB
IRAK1
Description
protein phosphatase 3 catalytic subunit beta
interleukin 1 receptor associated kinase 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Calcineurin Complex
Protein Serine/threonine Phosphatase Complex
Z Disc
T-tubule
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Protein-containing Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Hydrolase Activity
Enzyme Binding
Protein Phosphatase 2B Binding
Calmodulin-dependent Protein Phosphatase Activity
Metal Ion Binding
Protein Dimerization Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Biological Process
T Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Mediated Cytotoxicity
Lymphangiogenesis
Protein Phosphorylation
Protein Dephosphorylation
Response To Stress
Lysosome Organization
Signal Transduction
Heart Development
Learning
Memory
Regulation Of Gene Expression
Dephosphorylation
Calcium-ion Regulated Exocytosis
Negative Regulation Of Signaling
T Cell Differentiation
Locomotion Involved In Locomotory Behavior
Calcineurin-NFAT Signaling Cascade
Response To Cytokine
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
T Cell Proliferation
T Cell Activation
T Cell Homeostasis
Negative Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Axon Extension
Skeletal Muscle Fiber Development
Regulation Of Insulin Secretion
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Calcineurin-mediated Signaling
Antibacterial Innate Immune Response
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Lysosome Organization
Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Toll Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
DARPP-32 events
Calcineurin activates NFAT
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
ROBO receptors bind AKAP5
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
32723749
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
19838195
26502338
26606652
26663301
33272962
)
Interacting Genes
20 interacting genes:
AATK
CABIN1
EGFR
FBXL17
IRAK1
IRF2
JUN
LMTK2
MARCHF7
MYOZ2
MYOZ3
NFATC2
PTK7
RCAN1
ROR2
RUNX1
SLC8A1
SLC8A2
SLC8A3
SOCS3
52 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP1CC
PPP3CB
PRDX1
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TBKBP1
TICAM2
TIFA
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
USP20
YTHDC2
Entrez ID
5532
3654
HPRD ID
00235
02235
Ensembl ID
ENSG00000107758
ENSG00000184216
Uniprot IDs
B7Z781
P16298
D3YTB5
P51617
PDB IDs
4OR9
4ORA
4ORC
6BFN
Enriched GO Terms of Interacting Partners
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Calcium:sodium Antiporter Activity
Eyelid Development In Camera-type Eye
Striated Muscle Cell Development
Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Calcium Ion Import Across Plasma Membrane
Calcium Ion Import Into Cytosol
Regulation Of Cardiac Conduction
Muscle Cell Development
Regulation Of Signal Transduction
Calcium Ion Import
Regulation Of Calcineurin-mediated Signaling
Calcium Ion Export Across Plasma Membrane
FATZ Binding
Negative Regulation Of Signal Transduction
Protein Phosphatase Inhibitor Activity
Transcription Factor AP-1 Complex
Protein Kinase Activity
Regulation Of Cell Communication
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Signaling
Telethonin Binding
Axon Terminus
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Export Across Plasma Membrane
Neuronal Cell Body
Axon
Negative Regulation Of Cardiocyte Differentiation
Calcium Ion Transport Into Cytosol
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Calcium Ion Transmembrane Import Into Cytosol
Cellular Developmental Process
Regulation Of Calcium-mediated Signaling
Inorganic Cation Import Across Plasma Membrane
Antiporter Activity
Negative Regulation Of Intracellular Signal Transduction
Synapse Organization
Postsynaptic Density
Transcription Cis-regulatory Region Binding
Calcineurin-NFAT Signaling Cascade
Learning Or Memory
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Calcium-mediated Signaling
Negative Regulation Of Smooth Muscle Cell Differentiation
Cell Surface Receptor Signaling Pathway
Sarcolemma
Memory
Intracellular Signaling Cassette
Response To Muscle Stretch
Coronary Vasculature Development
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Innate Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Innate Immune Response
Response To External Biotic Stimulus
Cell Surface Toll-like Receptor Signaling Pathway
Response To Other Organism
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Activation Of Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
Immune Response
Regulation Of Intracellular Signal Transduction
Defense Response To Symbiont
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Cytokine Production
Signal Transduction
Intracellular Signaling Cassette
Signaling Adaptor Activity
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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