PPP3CB and IRF2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PPP3CB	IRF2
Description		protein phosphatase 3 catalytic subunit beta	interferon regulatory factor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5	Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978) Type 1 diabetes ( 34012112)
Interacting Genes		20 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3	24 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFE2L2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63
Entrez ID		5532	3660
HPRD ID		00235	00962
Ensembl ID		ENSG00000107758	ENSG00000168310
Uniprot IDs		B7Z781 P16298	P14316
PDB IDs		4OR9 4ORA 4ORC	8YTG
Enriched GO Terms of Interacting Partners?		Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Cytokine Transcription Cis-regulatory Region Binding Response To Peptide Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Glucose Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Response To Hormone Defense Response Nucleoplasm Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cellular Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process
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