PPP3CB and NFATC2

Number of citations of the paper that reports this interaction (PMID 11030334)
102

Data Source:
HPRD (in vitro, in vivo)

		PPP3CB	NFATC2
Gene Name		protein phosphatase 3, catalytic subunit, beta isozyme	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Ribonucleoprotein Complex Nuclear Transcription Factor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Protein Phosphorylation Protein Dephosphorylation Signal Transduction Heart Development Learning Memory Dephosphorylation Calcium Ion-dependent Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Social Behavior Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Positive Regulation Of NFAT Protein Import Into Nucleus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Cell Migration Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter B Cell Receptor Signaling Pathway
Pathways		Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling	Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CABIN1 IRAK1 IRF2 JUN MARCH7 MYOZ2 MYOZ3 NFATC2 SLC8A1 SLC8A2 SLC8A3 SOCS3	19 interactors: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 JUN MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ
Entrez ID		5532	4773
HPRD ID		00235	02730
Ensembl ID		ENSG00000107758	ENSG00000101096
Uniprot IDs		P16298	B5B2P0 B5B2P2 B5B2P3 B5B2P4 Q13469
PDB IDs			1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?		Calcium Ion Export Response To Wounding Innate Immune Response Response To Organonitrogen Compound Response To Stress Blood Coagulation Hemostasis Response To Purine-containing Compound Cellular Response To Organic Substance Cell Communication Sodium Ion Transmembrane Transport Regulation Of Body Fluid Levels Calcium Ion Import Calcium Ion Transmembrane Transport Wound Healing Immune Response Regulation Of Innate Immune Response Immune System Process Sodium Ion Transport Defense Response Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Response To Cytokine Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Toll-like Receptor TLR1:TLR2 Signaling Pathway Calcium Ion Transport Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Cellular Response To Potassium Ion Starvation MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Calcium Ion Import Into Cell Calcium Ion Export From Cell Leading Edge Cell Differentiation Sodium Ion Import Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Cytokine-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Immune Response-regulating Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Immune Response Regulation Of Metabolic Process Defense Response Innate Immune Response Positive Regulation Of Interleukin-4 Production Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Signaling Cell Activation Regulation Of Interleukin-4 Production Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Leukocyte Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Regulation Of Signal Transduction Gene Expression Regulation Of CD4-positive, Alpha-beta T Cell Differentiation N-terminal Peptidyl-lysine Acetylation Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cytokine Production Internal Protein Amino Acid Acetylation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Acetylation Leukocyte Differentiation Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway T Cell Differentiation Positive Regulation Of Cytokine Production RNA Metabolic Process Regulation Of Apoptotic Process
Tagcloud ?		actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled	calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Difference) ?		actinin aligned bigenic cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled	deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf
Tagcloud (Intersection) ?		calcineurin