ADI1 and APPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADI1	APPL1
Description		acireductone dioxygenase 1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse
	Molecular Function	Iron Ion Binding Protein Binding Acireductone Dioxygenase (Ni2+-requiring) Activity Acireductone Dioxygenase [iron(II)-requiring] Activity Nickel Cation Binding Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Methionine Metabolic Process Amino Acid Biosynthetic Process Methionine Biosynthetic Process L-methionine Salvage From Methylthioadenosine	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Methionine salvage pathway	Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		3 interacting genes: APP APPL1 MMP14	72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829
Entrez ID		55256	26060
HPRD ID		17607	05053
Ensembl ID		ENSG00000182551	ENSG00000157500
Uniprot IDs		Q9BV57	Q9UKG1
PDB IDs		4QGN 7JXG	2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?		Macropinosome Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Golgi Lumen Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Calcium-mediated Signaling Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Localization Cytoplasmic Vesicle Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Response To Odorant Regulation Of Protein Localization To Membrane Positive Regulation Of Macropinocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process
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