ADI1

Description		acireductone dioxygenase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Iron Ion Binding Protein Binding Acireductone Dioxygenase (Ni2+-requiring) Activity Acireductone Dioxygenase [iron(II)-requiring] Activity Nickel Cation Binding Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Methionine Metabolic Process Amino Acid Biosynthetic Process Methionine Biosynthetic Process L-methionine Salvage From Methylthioadenosine
Pathways		Methionine salvage pathway
Drugs
Diseases
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		1 novel interacting genes: MAPK7
Interacting Genes		3 interacting genes: APP APPL1 MMP14
Entrez ID		55256
HPRD ID		17607
Ensembl ID		ENSG00000182551
Uniprot IDs		Q9BV57
PDB IDs		4QGN 7JXG
Enriched GO Terms of Interacting Partners?		Macropinosome Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Golgi Lumen Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Calcium-mediated Signaling Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Localization Cytoplasmic Vesicle Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Response To Odorant Regulation Of Protein Localization To Membrane Positive Regulation Of Macropinocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway
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