DPPA4 and EIF4A2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DPPA4	EIF4A2
Description		developmental pluripotency associated 4	eukaryotic translation initiation factor 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	System Development Lung-associated Mesenchyme Development	Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM	25 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 FTCD GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 RIPPLY3 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		55211	1974
HPRD ID		16836	03062
Ensembl ID		ENSG00000121570	ENSG00000156976
Uniprot IDs		Q7L190	Q14240
PDB IDs			3BOR
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome	Centrosome Cycle Regulation Of Cell Cycle Eukaryotic Translation Initiation Factor 4F Complex Microtubule Organizing Center Organization
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