DPPA4 and TLK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPPA4	TLK1
Description		developmental pluripotency associated 4	tousled like kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	System Development Lung-associated Mesenchyme Development	Chromatin Organization Protein Phosphorylation Intracellular Protein Transport DNA Damage Response Chromosome Segregation Intracellular Signal Transduction Regulation Of Chromatin Organization
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)
Drugs			Fostamatinib
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)	Autism spectrum disorder ( 34069769) Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 27863252 32888494)
Interacting Genes		37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM	27 interacting genes: ASF1A ASF1B AURKA BEND7 CHEK1 DPPA4 GPRASP3 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22
Entrez ID		55211	9874
HPRD ID		16836	12232
Ensembl ID		ENSG00000121570	ENSG00000198586
Uniprot IDs		Q7L190	B3KRP1 Q9UKI8
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome	Regulation Of Mitotic Cell Cycle Nucleus Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Chromatin Organization Chromatin Remodeling Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Telencephalon Regionalization Regulation Of Cell Cycle G2/M Phase Transition DNA Replication-dependent Chromatin Assembly Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Chaperone Activity Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cerebral Cortex Development Nucleoplasm Protein Localization To Organelle Protein Localization To Chromosome Nucleosome Assembly RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Replication Fork Protein Binding Regulation Of DNA Recombination Mitotic G2 DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Mitotic Cell Cycle Protein-containing Complex Chromatin Negative Regulation Of DNA Metabolic Process DNA Binding Nucleosome Organization Positive Regulation Of Metalloendopeptidase Activity Astrocyte Differentiation Forebrain-midbrain Boundary Formation Pancreatic A Cell Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Protein Export From Nucleus Negative Regulation Of Telomere Maintenance
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