EIF4A2 and TRIM36

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		EIF4A2	TRIM36
Description		eukaryotic translation initiation factor 4A2	tripartite motif containing 36
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Acrosomal Vesicle Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Alpha-tubulin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Mitotic Cytokinesis Spindle Organization Acrosome Reaction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Diastolic blood pressure ( 27618452 27841878 28739976 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Left-handedness ( 32989287) Malaria ( 31844061) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		25 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 FTCD GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 RIPPLY3 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	11 interacting genes: BTRC EIF4A2 GLRX3 GRB7 TRAF3IP3 UBC UBE2D2 UBE2H ZMAT2 ZNF417 ZNF587
Entrez ID		1974	55521
HPRD ID		03062	15554
Ensembl ID		ENSG00000156976	ENSG00000152503
Uniprot IDs		Q14240	E9PBG3 Q4R1Q4 Q9NQ86
PDB IDs		3BOR	7QS4
Enriched GO Terms of Interacting Partners?		Centrosome Cycle Regulation Of Cell Cycle Eukaryotic Translation Initiation Factor 4F Complex Microtubule Organizing Center Organization	Protein K48-linked Ubiquitination Negative Regulation Of RNA-dependent RNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Protein Phosphorylated Amino Acid Binding Post-translational Protein Modification
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