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EIF4A2 and NEK2
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
EIF4A2
NEK2
Description
eukaryotic translation initiation factor 4A2
NIMA related kinase 2
Image
GO Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 4F Complex
Perinuclear Region Of Cytoplasm
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Midbody
Nuclear Lumen
Protein-containing Complex
Ciliary Basal Body
Intercellular Bridge
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
RNA Binding
RNA Helicase Activity
Translation Initiation Factor Activity
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Cytoplasmic Translational Initiation
Translation
Translational Initiation
Regulation Of Translational Initiation
Negative Regulation Of RNA-dependent RNA Polymerase Activity
Cellular Response To Leukemia Inhibitory Factor
Mitotic Sister Chromatid Segregation
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Telomere Maintenance
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Negative Regulation Of Centriole-centriole Cohesion
Pathways
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
M-decay: degradation of maternal mRNAs by maternally stored factors
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs
5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide
Fostamatinib
Diseases
GWAS
Red cell distribution width (
27863252
28957414
32888494
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
25 interacting genes:
BRCA1
CLNS1A
DPPA4
ECT2
EIF4G1
EIF4G2
FTCD
GOLGA2
HSPB2
IPO11
LINC01554
MCPH1
MDFI
NEK2
PDCD4
PFDN1
PIH1D2
RIPPLY3
SLC16A9
SSX2IP
SUMO2
TK1
TRIM36
TRIM39
ZNF620
29 interacting genes:
CDC20
CEP250
CHGA
CIP2A
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
FZR1
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PIN1
PPP1CA
PPP1CC
PPP1R2
PRKN
PTPRD
SMURF1
SPTBN4
TCF25
TPM3
Entrez ID
1974
4751
HPRD ID
03062
04953
Ensembl ID
ENSG00000156976
ENSG00000117650
Uniprot IDs
Q14240
F6U4U2
P51955
PDB IDs
3BOR
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
5M51
5M53
5M55
5M57
6SGD
6SGH
6SGI
6SGK
6SK9
6TM5
Enriched GO Terms of Interacting Partners
?
Centrosome Cycle
Regulation Of Cell Cycle
Eukaryotic Translation Initiation Factor 4F Complex
Microtubule Organizing Center Organization
Centrosome
Regulation Of Organelle Organization
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Ciliary Basal Body
Positive Regulation Of Microtubule Nucleation
Regulation Of Cell Cycle Process
Regulation Of Cellular Component Organization
Ubiquitin Ligase Activator Activity
Positive Regulation Of Organelle Organization
Intracellular Signal Transduction
Organelle Organization
Positive Regulation Of Cellular Component Organization
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle Checkpoint
Regulation Of Microtubule Nucleation
Neuron Cellular Homeostasis
Regulation Of Centriole-centriole Cohesion
Neuronal Cell Body
Axon Initial Segment
Regulation Of Nuclear Division
Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Meiotic Cell Cycle Phase Transition
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Spindle Pole
Regulation Of Cell Cycle
Acinar Cell Differentiation
Synapse Organization
Chromosome, Centromeric Region
Kinetochore
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Microtubule Polymerization
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Ubiquitin Protein Ligase Activity
Hematopoietic Or Lymphoid Organ Development
Cell Division
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Trachea Formation
PTW/PP1 Phosphatase Complex
Negative Regulation Of Mitotic Nuclear Division
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Cytoskeleton
Cytosol
Regulation Of Circadian Rhythm
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Tagcloud (Difference)
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Tagcloud (Intersection)
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