DPPA4 and KAT14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPPA4	KAT14
Description		developmental pluripotency associated 4	lysine acetyltransferase 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Mitotic Spindle ATAC Complex
	Molecular Function	Chromatin Binding Protein Binding	Histone Acetyltransferase Activity Protein Binding Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups LIM Domain Binding
	Biological Process	System Development Lung-associated Mesenchyme Development	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)	Thyroglobulin plasma levels ( 30929638)
Interacting Genes		37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM	11 interacting genes: ACTC1 CEP70 CSRP2 DPPA4 H3C1 H4C1 H4C16 MBIP TRIM27 TRIM54 ZFY
Entrez ID		55211	57325
HPRD ID		16836	16765
Ensembl ID		ENSG00000121570	ENSG00000149474
Uniprot IDs		Q7L190	A0A075B6H4 Q9H8E8
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome	Nucleosome Telomere Organization Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein-DNA Complex Assembly Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Protein Localization To Chromatin Chromatin Remodeling Protein Heterodimerization Activity Chromosome Organization Chromatin Organization Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Actomyosin Structure Organization Organelle Organization Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration Z Disc
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