EIF4A2

Description		eukaryotic translation initiation factor 4A2
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
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Diseases
GWAS
Interacting Genes		25 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 FTCD GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 RIPPLY3 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		1974
HPRD ID		03062
Ensembl ID		ENSG00000156976
Uniprot IDs		Q14240
PDB IDs		3BOR
Enriched GO Terms of Interacting Partners?		Centrosome Cycle Regulation Of Cell Cycle Eukaryotic Translation Initiation Factor 4F Complex Microtubule Organizing Center Organization
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