DPPA4 and GMPPB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPPA4	GMPPB
Description		developmental pluripotency associated 4	GDP-mannose pyrophosphorylase B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Cytosol GDP-mannose Pyrophosphorylase Complex
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding Mannose-1-phosphate Guanylyltransferase (GTP) Activity Protein Binding GTP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	System Development Lung-associated Mesenchyme Development	Protein Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Metabolic Process GDP-mannose Biosynthetic Process From Mannose
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Zygotic genome activation (ZGA)	Synthesis of GDP-mannose
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Multisite chronic pain ( 31194737) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633)
Interacting Genes		37 interacting genes: BTBD2 CIRSR CRK DPPA2 EAF1 EIF4A2 EMD FOXR1 GMPPB GRAP GRB2 GTPBP3 HTT INO80B KAT14 LDOC1 MAGOH MAP1LC3A MAP1LC3B MAPK6 MISP NEDD9 OSTF1 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 SNX18 SNX33 SPANXN2 TLK1 TNIP1 VIM	5 interacting genes: DPPA4 GLYCTK GMPPA POLR1C TXNDC5
Entrez ID		55211	29925
HPRD ID		16836	13589
Ensembl ID		ENSG00000121570	ENSG00000173540
Uniprot IDs		Q7L190	Q9Y5P6
PDB IDs			7D72 7D73 7D74
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cytoplasm Protein Binding Cellular Response To Muramyl Dipeptide Cellular Response To Nitrogen Starvation Cleavage Furrow Formation Import Into Cell Endocytosis Central Nervous System Development Phosphatidylethanolamine Binding Plasma Membrane Tubulation Organelle Organization Spindle Pole Centrosome	Molecular Sensor Activity GDP-mannose Pyrophosphorylase Complex Mannose-1-phosphate Guanylyltransferase (GTP) Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity
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