EIF4A2 and CLNS1A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		EIF4A2	CLNS1A
Gene Name		eukaryotic translation initiation factor 4A2	chloride channel, nucleotide-sensitive, 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Methylosome PICln-Sm Protein Complex
	Molecular Function	Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of RNA-directed RNA Polymerase Activity	Spliceosomal SnRNP Assembly Chloride Transport Cell Volume Homeostasis Gene Expression NcRNA Metabolic Process
Pathways		Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 IPO11 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP TK1 TRIM36 TRIM39	18 interactors: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 ITGA2B LSM10 LSM2 LSM3 LSM6 PRMT5 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG
Entrez ID		1974	1207
HPRD ID		03062	03694
Ensembl ID		ENSG00000156976	ENSG00000074201
Uniprot IDs		Q14240 Q9NZE6	E9PJF4 P54105
PDB IDs		3BOR
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Centrosome Organization Microtubule Organizing Center Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Microtubule-based Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Binding Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Histone H4-K16 Acetylation Fetal Process Involved In Parturition Regulation Of Translational Initiation Regulation Of JUN Kinase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Chromosome Segregation Cell Cycle Regulation Of DNA Binding Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Binding Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centriole-centriole Cohesion Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Apoptotic Process Cellular Response To Indole-3-methanol Regulation Of Mitotic Centrosome Separation Programmed Cell Death Regulation Of Cell Cycle Process Developmental Process Ribosomal Protein Import Into Nucleus Intraciliary Transport Involved In Cilium Morphogenesis Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Cell Cycle Process Regulation Of Cytoskeleton Organization Response To Ionizing Radiation Dosage Compensation By Inactivation Of X Chromosome Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization	MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Histone MRNA Metabolic Process MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing DNA-templated Transcription, Termination NcRNA Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cortical Actin Cytoskeleton Organization RNA Biosynthetic Process Cortical Cytoskeleton Organization Aromatic Compound Catabolic Process Platelet Aggregation Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RNA-directed RNA Polymerase Activity Neuron Projection Morphogenesis Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cellular Macromolecule Catabolic Process Cell Part Morphogenesis Regulation Of Mitotic Cell Cycle
Tagcloud ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Difference) ?		4f adult biogenesis confer deprivation differed differs eif4f eif4g1 fetal gestation helicase hepatocyte insensitive liver nutrient oligopyrimidine preinitiation rapamycin refeeding ribosome sensing top tracts translation weights went
Tagcloud (Intersection) ?