VPS37C and PDCD6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		VPS37C	PDCD6
Gene Name		vacuolar protein sorting 37 homolog C (S. cerevisiae)	programmed cell death 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Binding, Bridging
	Biological Process	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Membrane Organization Intracellular Transport Of Virus	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Proteolysis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ABI2 AES APP C1orf94 CEP55 DAZAP2 DDIT3 FAM168A GOLGA2 HGS HNRNPUL1 MAPK1IP1L PDCD6 PDCD6IP PKNOX1 PLSCR1 PSMA3 RBPMS RFX6 RINT1 SH3GL1 SORBS2 SORBS3 STAM2 TACC3 TFG TFIP11 TSG101 UBC VPS28 WWP2 XIAP	18 interactors: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		55048	10016
HPRD ID		15652	03035
Ensembl ID		ENSG00000167987	ENSG00000249915
Uniprot IDs		A5D8V6	O75340 Q53FC3
PDB IDs			2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK
Enriched GO Terms of Interacting Partners?		Virion Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of ERBB Signaling Pathway Viral Life Cycle Cellular Protein Catabolic Process Endosomal Transport Intracellular Transport Of Virus Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Apoptotic Process Programmed Cell Death Regulation Of Cellular Process Cell Death Regulation Of Extracellular Vesicular Exosome Assembly Death Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Viral Process Intracellular Transport Cellular Macromolecule Catabolic Process Viral Budding Membrane Organization Gene Expression Positive Regulation Of Exocytosis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Cell Cycle Regulation Of Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter Protein Processing Negative Regulation Of Signal Transduction Establishment Of Protein Localization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Localization Positive Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Cell Separation After Cytokinesis	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Cell Death Death Positive Regulation Of Peptidase Activity Programmed Necrotic Cell Death Necrotic Cell Death Necroptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Inorganic Substance Membrane Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Response To Metal Ion Response To Calcium Ion Apoptotic Signaling Pathway T Cell Apoptotic Process Cell Separation After Cytokinesis Regulation Of Endopeptidase Activity Virion Assembly Regulation Of Peptidase Activity Necroptotic Process Regulation Of Cell Death Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Motor Neuron Apoptotic Process Regulation Of Apoptotic Process Mitochondrion Organization Cytokinesis, Completion Of Separation Senescence-associated Heterochromatin Focus Assembly Endosomal Lumen Acidification
Tagcloud ?		bl bud budding cargo degrade escrt hairpin hijacks jr k38a multivesicular mvb nl4 p6 polyproteins pppy producer pseudovirus ptap retroviral retrovirus retroviruses tank tbk1 tethering tzm ubiquitylated ultrastructure vero	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Difference) ?		bl bud budding cargo degrade escrt hairpin hijacks jr k38a multivesicular mvb nl4 p6 polyproteins pppy producer pseudovirus ptap retroviral retrovirus retroviruses tank tbk1 tethering tzm ubiquitylated ultrastructure vero	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Intersection) ?