VPS37C and FUBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VPS37C	FUBP1
Description		VPS37C subunit of ESCRT-I	far upstream element binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Endosome Golgi Apparatus Cilium Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs			Irofulven Sacituzumab govitecan
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)	A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Hip circumference adjusted for BMI ( 34021172) Lung cancer in never smokers ( 28604730) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34	25 interacting genes: AIMP2 ANXA11 CCNH CEBPA CELF1 CHD3 CRMP1 ESR1 GTF2H1 IMMT MAPK1IP1L MYOC PRPF40B PRR13 PUF60 SIRPA SMN1 SMURF2 SNRPA SNRPC TIAL1 TLE1 U2AF2 VIM VPS37C
Entrez ID		55048	8880
HPRD ID		15652	10349
Ensembl ID		ENSG00000167987	ENSG00000162613
Uniprot IDs		A5D8V6	A0A384MDX9 A0A994J3Q8 B4DT31 C9JSZ1 Q96AE4
PDB IDs			1J4W 2KXH 4LIJ 6Y24 6Y2C 6Y2D 8P25
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Primary Metabolic Process Late Endosome To Vacuole Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Exosomal Secretion Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT-0 Complex Positive Regulation Of RNA Metabolic Process Endosome Organization Membrane Fission Regulation Of Protein Ubiquitination Regulation Of Exosomal Secretion Multivesicular Body Sorting Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Cytoplasmic Stress Granule Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Viral Budding Via Host ESCRT Complex Protein Serine/threonine Kinase Binding COPII Vesicle Coating Positive Regulation Of Protein Monoubiquitination Positive Regulation Of JNK Cascade Ubiquitin Binding Positive Regulation Of Transcription By RNA Polymerase II Macroautophagy Nucleus Viral Budding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Extracellular Exosome Assembly Regulation Of Protein Monoubiquitination Positive Regulation Of Supramolecular Fiber Organization Establishment Of Protein Localization To Vacuole Vesicle Organization Transcription Regulator Complex Regulation Of Post-translational Protein Modification Cytosol Endoplasmic Reticulum Exit Site Protein Dimerization Activity Positive Regulation Of Macromolecule Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing Nucleoplasm RNA Metabolic Process MRNA Processing U2-type Prespliceosome U1 SnRNP Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Metabolic Process Commitment Complex Nucleic Acid Metabolic Process U1 SnRNA Binding Nucleus Nucleobase-containing Compound Metabolic Process Transcription Factor TFIIH Core Complex Nucleic Acid Binding Transcription Factor TFIIH Holo Complex RNA Processing Transcription By RNA Polymerase I Negative Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Regulation Of MRNA Splicing, Via Spliceosome Nuclear Matrix Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Skeletal Muscle Hypertrophy Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly
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