VPS37C and AARD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VPS37C	AARD
Description		VPS37C subunit of ESCRT-I	alanine and arginine rich domain containing protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Endosome Golgi Apparatus Cilium Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Protein Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Response To Testosterone
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)
Interacting Genes		102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34	15 interacting genes: CENPQ CEP57 GRIPAP1 KIAA0753 KRT24 KRT27 LMO4 MAGEB4 NTAQ1 STX1A STX2 STX5 TFIP11 TSGA10 VPS37C
Entrez ID		55048	441376
HPRD ID		15652	18830
Ensembl ID		ENSG00000167987	ENSG00000205002
Uniprot IDs		A5D8V6	B2RU19 Q4LEZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Primary Metabolic Process Late Endosome To Vacuole Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Exosomal Secretion Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT-0 Complex Positive Regulation Of RNA Metabolic Process Endosome Organization Membrane Fission Regulation Of Protein Ubiquitination Regulation Of Exosomal Secretion Multivesicular Body Sorting Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Cytoplasmic Stress Granule Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Viral Budding Via Host ESCRT Complex Protein Serine/threonine Kinase Binding COPII Vesicle Coating Positive Regulation Of Protein Monoubiquitination Positive Regulation Of JNK Cascade Ubiquitin Binding Positive Regulation Of Transcription By RNA Polymerase II Macroautophagy Nucleus Viral Budding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Extracellular Exosome Assembly Regulation Of Protein Monoubiquitination Positive Regulation Of Supramolecular Fiber Organization Establishment Of Protein Localization To Vacuole Vesicle Organization Transcription Regulator Complex Regulation Of Post-translational Protein Modification Cytosol Endoplasmic Reticulum Exit Site Protein Dimerization Activity Positive Regulation Of Macromolecule Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	SNARE Complex SNAP Receptor Activity SNARE Binding Vesicle Docking Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Vesicle Organization Organelle Fusion Presynaptic Active Zone Membrane Membrane Fusion Structural Molecule Activity Organelle Organization Organelle Localization Myosin Head/neck Binding Protein-N-terminal Glutamine Amidohydrolase Activity Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Intracellular Protein Transport Structural Constituent Of Skin Epidermis Endomembrane System Protein Transport Spliceosomal Complex Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore Negative Regulation Of Receptor Clustering Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Intermediate Filament Organization Membrane Organization Intracellular Protein Localization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Ventral Spinal Cord Interneuron Differentiation U2-type Post-mRNA Release Spliceosomal Complex Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Establishment Of Protein Localization
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