PDCD6 and IGFALS

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (in vivo)

		PDCD6	IGFALS
Description		programmed cell death 6	insulin like growth factor binding protein acid labile subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Exit Site	Extracellular Region Extracellular Space Insulin-like Growth Factor Ternary Complex Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Insulin-like Growth Factor Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Cell Adhesion Signal Transduction
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576) Insulin-like growth factors ( 21216879) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		29 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CEBPA CPNE1 CPNE2 CPNE4 DIAPH3 FAS FASLG FNDC3A HEBP2 IGFALS KLHL12 MAP3K5 MAPK1IP1L MIA2 PDCD6IP PEF1 PRR19 SARAF SEC31A SH3KBP1 SHISA4 TIMM22 UBC VPS37C YWHAQ	4 interacting genes: IGF1 IGFBP3 IGFBP5 PDCD6
Entrez ID		10016	3483
HPRD ID		03035	03290
Ensembl ID		ENSG00000249915	ENSG00000099769
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	P35858 Q8TAY0
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ	7WRQ
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Calcium-dependent Protein Binding Response To Calcium Ion Calcium-dependent Phospholipid Binding Extracellular Exosome COPII Vesicle Coat Endoplasmic Reticulum Exit Site Vesicle Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Necroptotic Signaling Pathway Vesicle-mediated Transport Phosphatidylserine Binding ESCRT I Complex Vesicle Organization Cellular Response To Metal Ion Replicative Senescence Cellular Response To Calcium Ion Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor Viral Budding Via Host ESCRT Complex Membrane Organization COPII Vesicle Coating Cellular Localization Viral Budding Autophagy Lymphocyte Apoptotic Process T Cell Apoptotic Process NF-kappaB Binding Ligase Inhibitor Activity Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Vesicle Cargo Loading Golgi Vesicle Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Negative Regulation Of MRNA Modification Multivesicular Body Organization Multivesicular Body Assembly Stem Cell Development Neural Crest Cell Development Vesicle Coating Stereocilia Tip-link Density COPII-coated ER To Golgi Transport Vesicle Cytokinetic Process Apoptotic Signaling Pathway	Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Regulation Of Smooth Muscle Cell Proliferation Insulin-like Growth Factor I Binding Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Growth Factor Binding Lung Alveolus Development Negative Regulation Of Signal Transduction Regulation Of Cell Growth Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Population Proliferation Striated Muscle Cell Differentiation Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Tissue Remodeling Positive Regulation Of Cell Migration Response To Heat Positive Regulation Of Cell Motility Epithelial To Mesenchymal Transition Negative Regulation Of Protein Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Growth Positive Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Regulation Of Glucose Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Muscle Cell Differentiation Negative Regulation Of Oocyte Development Mesenchymal Cell Differentiation Negative Regulation Of Skeletal Muscle Hypertrophy
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