PDCD6 and FNDC3A

Number of citations: 53 (PubMedID 32878247)
Data Source: BioGRID (far western blotting)

		PDCD6	FNDC3A
Name		programmed cell death 6	fibronectin type III domain containing 3A
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Exit Site	Golgi Membrane Acrosomal Vesicle Cytoplasm Golgi Apparatus Cytosol Endomembrane System Vesicle Membrane Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Spermatid Development Fertilization Sertoli Cell Development Cell-cell Adhesion
Drugs		Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate	None
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Waist circumference adjusted for body mass index ( 34021172 )	Apolipoprotein A1 levels ( 32203549 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol levels ( 32203549 ) Pelvic organ prolapse ( 26545240 ) Spontaneous preterm birth with premature rupture of membranes ( 31194736 ) Trunk fat mass ( 28552196 )
Novel Interactors		1 novel interactors: TERT	1 novel interactors: NUDT15
Interacting Genes		29 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CEBPA CPNE1 CPNE2 CPNE4 DIAPH3 FAS FASLG FNDC3A HEBP2 IGFALS KLHL12 MAP3K5 MAPK1IP1L MIA2 PDCD6IP PEF1 PRR19 SARAF SEC31A SH3KBP1 SHISA4 TIMM22 UBC VPS37C YWHAQ	2 interacting genes: APP PDCD6
Entrez ID		10016	22862
HPRD ID		03035	13548
Ensembl ID		ENSG00000249915	ENSG00000102531
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	Q9Y2H6
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ	1WK0 1X3D 1X4X 1X5X 2CRM 2CRZ
GO Terms Enriched among Interactors		Response To Metal Ion Calcium-dependent Protein Binding Response To Calcium Ion Calcium-dependent Phospholipid Binding Extracellular Exosome COPII Vesicle Coat Endoplasmic Reticulum Exit Site Vesicle Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Necroptotic Signaling Pathway Vesicle-mediated Transport Phosphatidylserine Binding ESCRT I Complex Vesicle Organization Cellular Response To Metal Ion Replicative Senescence Cellular Response To Calcium Ion Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor Viral Budding Via Host ESCRT Complex Membrane Organization COPII Vesicle Coating Cellular Localization Viral Budding Autophagy Lymphocyte Apoptotic Process T Cell Apoptotic Process NF-kappaB Binding Ligase Inhibitor Activity Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Vesicle Cargo Loading Golgi Vesicle Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Negative Regulation Of MRNA Modification Multivesicular Body Organization Multivesicular Body Assembly Stem Cell Development Neural Crest Cell Development Vesicle Coating Stereocilia Tip-link Density COPII-coated ER To Golgi Transport Vesicle Cytokinetic Process Apoptotic Signaling Pathway	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Monoubiquitination 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Purine Deoxyribonucleoside Triphosphate Catabolic Process 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Deoxyribonucleoside Triphosphate Catabolic Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Toll Signaling Pathway Regulation Of Protein Monoubiquitination Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Response To Metal Ion Axon Choice Point Recognition Protein Heterodimerization Activity Nucleoside Triphosphate Diphosphatase Activity DNA Protection Regulation Of Protein Catabolic Process Heparan Sulfate Binding