PDCD6 and DIAPH3

Number of citations of the paper that reports this interaction (PubMedID 32878247)
53

Data Source:
BioGRID (far western blotting)

		PDCD6	DIAPH3
Description		programmed cell death 6	diaphanous related formin 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Exit Site	ESCRT I Complex Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Actin Filament Filamentous Actin Cleavage Furrow Actin Filament Bundle Ribbon Synapse Stereocilia Tip-link Density
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Metal Ion Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Actin Binding Microtubule Binding Cytoskeletal Protein Binding Small GTPase Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Microtubule Cytoskeleton Organization In Utero Embryonic Development Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Integrin-mediated Signaling Pathway Sensory Perception Of Sound Gene Expression Endosomal Transport Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Differentiation Erythrocyte Differentiation Macrophage Differentiation Protein-containing Complex Remodeling Erythrocyte Enucleation Actin Nucleation Microtubule Polymerization Actin Filament Bundle Assembly Actin Crosslink Formation Inner Ear Receptor Cell Differentiation Head Development Autophagosome-lysosome Fusion Podosome Assembly
Pathways			RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs		Calcium Zinc Calcium citrate Calcium Phosphate Calcium phosphate dihydrate Zinc acetate
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Age at first sexual intercourse ( 27089180 34211149) Body mass index ( 28892062) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) HOMA-B (corrected for HOMA-IR) ( 30369944) Metabolite levels ( 23823483) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Number of sexual partners ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		29 interacting genes: ANXA11 ANXA7 BAG4 CDKN2A CEBPA CPNE1 CPNE2 CPNE4 DIAPH3 FAS FASLG FNDC3A HEBP2 IGFALS KLHL12 MAP3K5 MAPK1IP1L MIA2 PDCD6IP PEF1 PRR19 SARAF SEC31A SH3KBP1 SHISA4 TIMM22 UBC VPS37C YWHAQ	6 interacting genes: CDC42 NCKIPSD PDCD6 RAC1 RHOA SMAD9
Entrez ID		10016	81624
HPRD ID		03035	10884
Ensembl ID		ENSG00000249915	ENSG00000139734
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	B4DPV3 Q9NSV4
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ	5UWP 6X2Y
Enriched GO Terms of Interacting Partners?		Response To Metal Ion Calcium-dependent Protein Binding Response To Calcium Ion Calcium-dependent Phospholipid Binding Extracellular Exosome COPII Vesicle Coat Endoplasmic Reticulum Exit Site Vesicle Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Necroptotic Signaling Pathway Vesicle-mediated Transport Phosphatidylserine Binding ESCRT I Complex Vesicle Organization Cellular Response To Metal Ion Replicative Senescence Cellular Response To Calcium Ion Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor Viral Budding Via Host ESCRT Complex Membrane Organization COPII Vesicle Coating Cellular Localization Viral Budding Autophagy Lymphocyte Apoptotic Process T Cell Apoptotic Process NF-kappaB Binding Ligase Inhibitor Activity Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Vesicle Cargo Loading Golgi Vesicle Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Negative Regulation Of MRNA Modification Multivesicular Body Organization Multivesicular Body Assembly Stem Cell Development Neural Crest Cell Development Vesicle Coating Stereocilia Tip-link Density COPII-coated ER To Golgi Transport Vesicle Cytokinetic Process Apoptotic Signaling Pathway	Postsynapse Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Synapse Organization G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Thioesterase Binding Regulation Of Postsynapse Organization Positive Regulation Of Cell Migration Establishment Or Maintenance Of Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Motility Cell-cell Junction Organization Positive Regulation Of Locomotion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Endothelial Cell Migration Polarized Epithelial Cell Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Positive Regulation Of Lamellipodium Organization Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Assembly Wnt Signaling Pathway Telencephalon Cell Migration Intracellular Signaling Cassette Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Regulation Of Postsynapse Assembly Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration
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