VPS37C and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VPS37C	POU2AF1
Description		VPS37C subunit of ESCRT-I	POU class 2 homeobox associating factor 1
Image		No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Endosome Golgi Apparatus Cilium Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding POU Domain Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Germinal Center B Cell Differentiation Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)	Brain morphology (MOSTest) ( 32665545) Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34	54 interacting genes: CCDC120 CIMIP2B DGCR6L FOXD2 GATA2 GPS2 GTF2H1 GTF2I HEMK1 HGS HOXC8 HOXC9 ITGB4 KLHL38 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 MEIS2 MSX2 NAB1 NDUFAF3 NOTCH1 OTX1 PAX8 PITX2 POGZ POU2F1 POU2F2 PTPN11 RAMAC RBM24 RHOXF2 ROR2 SCAND1 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK TBX6 TENT5B TFG TLX3 USP2 VGLL3 VPS37C YPEL3 ZNF414 ZNF581
Entrez ID		55048	5450
HPRD ID		15652	03126
Ensembl ID		ENSG00000167987	ENSG00000110777
Uniprot IDs		A5D8V6	Q16633
PDB IDs			1CQT
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Primary Metabolic Process Late Endosome To Vacuole Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Exosomal Secretion Endosome Transport Via Multivesicular Body Sorting Pathway ESCRT-0 Complex Positive Regulation Of RNA Metabolic Process Endosome Organization Membrane Fission Regulation Of Protein Ubiquitination Regulation Of Exosomal Secretion Multivesicular Body Sorting Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of JNK Cascade Cytoplasmic Stress Granule Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Viral Budding Via Host ESCRT Complex Protein Serine/threonine Kinase Binding COPII Vesicle Coating Positive Regulation Of Protein Monoubiquitination Positive Regulation Of JNK Cascade Ubiquitin Binding Positive Regulation Of Transcription By RNA Polymerase II Macroautophagy Nucleus Viral Budding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Extracellular Exosome Assembly Regulation Of Protein Monoubiquitination Positive Regulation Of Supramolecular Fiber Organization Establishment Of Protein Localization To Vacuole Vesicle Organization Transcription Regulator Complex Regulation Of Post-translational Protein Modification Cytosol Endoplasmic Reticulum Exit Site Protein Dimerization Activity Positive Regulation Of Macromolecule Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Pattern Specification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Serotonin Transport Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Pyrimidine Nucleoside Transmembrane Transporter Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intermediate Filament Anterior/posterior Pattern Specification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Putrescine Transmembrane Transporter Activity Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Nephron Tubule Development Embryonic Morphogenesis Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Renal Tubule Development Kidney Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Embryonic Hindlimb Morphogenesis Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport
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