PDCD6 and CPNE4

Number of citations of the paper that reports this interaction (PMID 12522145)
20

Data Source:
HPRD (in vitro, two hybrid)

		PDCD6	CPNE4
Gene Name		programmed cell death 6	copine IV
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site	Extracellular Vesicular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Binding, Bridging
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Proteolysis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 22959728) Neutrophil count ( 21507922)
Protein-Protein Interactions		18 interactors: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SH3KBP1 TIMM22 VPS37C YWHAQ	16 interactors: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O
Entrez ID		10016	131034
HPRD ID		03035	05017
Ensembl ID		ENSG00000249915	ENSG00000196353
Uniprot IDs		O75340 Q53FC3	Q96A23
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK
Enriched GO Terms of Interacting Partners?		Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Cell Death Death Positive Regulation Of Peptidase Activity Programmed Necrotic Cell Death Necrotic Cell Death Necroptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Inorganic Substance Membrane Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Response To Metal Ion Response To Calcium Ion Apoptotic Signaling Pathway T Cell Apoptotic Process Cell Separation After Cytokinesis Regulation Of Endopeptidase Activity Virion Assembly Regulation Of Peptidase Activity Necroptotic Process Regulation Of Cell Death Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Motor Neuron Apoptotic Process Regulation Of Apoptotic Process Mitochondrion Organization Cytokinesis, Completion Of Separation Senescence-associated Heterochromatin Focus Assembly Endosomal Lumen Acidification	Cellular Component Assembly Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Protein Heterooligomerization Golgi To Plasma Membrane Transport Intracellular Transport Protein Monoubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Actin Filament Capping Organelle Transport Along Microtubule Cell Projection Organization Regulation Of Proteinase Activated Receptor Activity Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Establishment Of Localization In Cell Negative Regulation Of Tooth Mineralization Negative Regulation Of Phospholipase C Activity Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Development Negative Regulation Of Protein Complex Disassembly Transport Cell Projection Morphogenesis Vesicle-mediated Transport Minus-end-directed Organelle Transport Along Microtubule Axon Guidance Cell Part Morphogenesis Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Protein Depolymerization Regulation Of Organelle Organization Regulation Of Golgi Inheritance Protein Oligomerization Regulation Of Protein Complex Disassembly Specification Of Axis Polarity Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Cellular Localization Negative Regulation Of Protein Complex Assembly Microtubule-based Transport Regulation Of Vascular Smooth Muscle Contraction Common-partner SMAD Protein Phosphorylation Negative Regulation Of Odontogenesis
Tagcloud ?		adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Difference) ?		adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Intersection) ?