PID1 and LRP1

Number of citations of the paper that reports this interaction (PMID 20205790)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PID1	LRP1
Gene Name		phosphotyrosine interaction domain containing 1	low density lipoprotein receptor-related protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function		Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Regulation Of Mitochondrial Fusion Cellular Response To Leptin Stimulus Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Fat Cell Proliferation Mitochondrion Morphogenesis Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Mitochondrial DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Pulmonary function (interaction) ( 23284291) Reasoning ( 21107309)	Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		13 interactors: ADAMTSL4 BANP CCDC33 CRX GOLGA2 GOPC KRTAP10-1 LRP1 MDFI NME1 NOTCH2NL SPERT THAP1	63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		55022	4035
HPRD ID		07944	00138
Ensembl ID		ENSG00000153823	ENSG00000123384
Uniprot IDs		Q7Z2X4	Q07954 Q59FG2
PDB IDs			1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Cytoplasmic Sequestering Of Protein Regulation Of Binding Cytoplasmic Sequestering Of CFTR Protein Beta-amyloid Clearance Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of DNA Binding Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Binding Negative Regulation Of Intracellular Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Protein Transport Developmental Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Golgi To Plasma Membrane Protein Transport	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell
Tagcloud ?		adaptor apla associates augmented changed confocal depending developmentally disrupted e3 est fe65 ligase localization motif nedd4 originally phosphotyrosine pid2 pplp pull putative subcellular tag ubiquitin ubiquitinated ubiquitylation w243kp245k ww	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		adaptor apla associates augmented changed confocal depending developmentally disrupted e3 est fe65 ligase localization motif nedd4 originally phosphotyrosine pid2 pplp pull putative subcellular tag ubiquitin ubiquitinated ubiquitylation w243kp245k ww	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?