LPAR3 and EDA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LPAR3	EDA
Description		lysophosphatidic acid receptor 3	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cilium Membrane Axon Synapse	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding Lysophosphatidic Acid Receptor Activity	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Gene Expression Bleb Assembly Positive Regulation Of MAPK Cascade Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Calcium Ion Transport	Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Dental caries ( 23064961) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		61 interacting genes: APP AQP6 ARL13B ASZ1 BCL2L13 C16orf54 CD53 CD74 CD79A CLDN2 CLDN7 CLDN9 CLEC12B CPLX4 CREB3L1 CYB561 CYBRD1 EDA ELOVL4 ERGIC3 FAM209A FAM210B FFAR2 FNDC9 GJB5 GNAI2 GORAB GPX8 HSD17B13 JAGN1 KCNC1 KCNJ6 LEPROTL1 LHFPL5 LIME1 LMNA MFF MGST3 MRM1 MS4A4A MUC1 NDUFAF2 OPRM1 PGRMC2 RELL2 RETREG3 SCN3B SGMS2 SHISAL1 SLC10A6 SLC16A2 SLC35H1 TFEC THAP4 TMEM14B TMEM237 TMEM31 TMEM41A TMEM52B TMEM70 TMEM79	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		23566	1896
HPRD ID		05486	02347
Ensembl ID		ENSG00000171517	ENSG00000158813
Uniprot IDs		Q9UBY5	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8 7X9G
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Ascorbate Homeostasis Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules B Cell Receptor Complex Transmembrane Monodehydroascorbate Reductase Activity Negative Regulation Of Protein Secretion Negative Regulation Of Secretion By Cell	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity
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