LPAR3 and GNAI2

Number of citations of the paper that reports this interaction (PMID 10727522)
32

Data Source:
HPRD (in vivo)

		LPAR3	GNAI2
Gene Name		lysophosphatidic acid receptor 3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Phospholipid Binding Lipid Binding Lysophosphatidic Acid Receptor Activity	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Bleb Assembly Positive Regulation Of Collateral Sprouting Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		2 interactors: APP GNAI2	64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A
Entrez ID		23566	2771
HPRD ID		05486	00764
Ensembl ID		ENSG00000171517	ENSG00000114353
Uniprot IDs		Q9UBY5	B3KP24 B3KX51 P04899
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Blood Coagulation Hemostasis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Body Fluid Levels Wound Healing Neuron Remodeling Cell Activation Response To Wounding Regulation Of Protein Kinase Activity Adenosine Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Copper Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Lyase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Regulation Of Phosphorylation Negative Regulation Of Nucleotide Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity
Tagcloud ?			aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?			aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?