LPAR3 and GPX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LPAR3	GPX8
Description		lysophosphatidic acid receptor 3	glutathione peroxidase 8 (putative)
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cilium Membrane Axon Synapse	Endoplasmic Reticulum Lumen Membrane
	Molecular Function	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding Lysophosphatidic Acid Receptor Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Gene Expression Bleb Assembly Positive Regulation Of MAPK Cascade Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Calcium Ion Transport	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	Detoxification of Reactive Oxygen Species
Drugs			Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Dental caries ( 23064961) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Cocaine dependence ( 31212010)
Interacting Genes		61 interacting genes: APP AQP6 ARL13B ASZ1 BCL2L13 C16orf54 CD53 CD74 CD79A CLDN2 CLDN7 CLDN9 CLEC12B CPLX4 CREB3L1 CYB561 CYBRD1 EDA ELOVL4 ERGIC3 FAM209A FAM210B FFAR2 FNDC9 GJB5 GNAI2 GORAB GPX8 HSD17B13 JAGN1 KCNC1 KCNJ6 LEPROTL1 LHFPL5 LIME1 LMNA MFF MGST3 MRM1 MS4A4A MUC1 NDUFAF2 OPRM1 PGRMC2 RELL2 RETREG3 SCN3B SGMS2 SHISAL1 SLC10A6 SLC16A2 SLC35H1 TFEC THAP4 TMEM14B TMEM237 TMEM31 TMEM41A TMEM52B TMEM70 TMEM79	170 interacting genes: AGTRAP AIG1 ALG8 ANKRD46 APOC3 APOD AQP1 AQP2 AQP3 ARLN ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 C3orf52 CACNG1 CCDC167 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLDND2 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CXCL16 CYB561 CYB561A3 CYB561D2 CYBC1 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GIMAP1 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 ITGAM KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NINJ2 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 RBFA RND1 RPRM RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 SYT15B TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM14B TMEM14C TMEM19 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 TSPO2 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22
Entrez ID		23566	493869
HPRD ID		05486	17416
Ensembl ID		ENSG00000171517	ENSG00000164294
Uniprot IDs		Q9UBY5	B4DPY0 E7ETY7 J3KNB5 Q8TED1
PDB IDs			3CYN 3KIJ
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Ascorbate Homeostasis Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules B Cell Receptor Complex Transmembrane Monodehydroascorbate Reductase Activity Negative Regulation Of Protein Secretion Negative Regulation Of Secretion By Cell	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Plasma Membrane SNAP Receptor Activity SNARE Complex Golgi Membrane Cholesterol Binding Water Channel Activity Glycerol Transmembrane Transport Transmembrane Transport Channel Activity Renal Water Transport Polyol Transmembrane Transport Glycerol Transmembrane Transporter Activity Vesicle-mediated Transport Lysosomal Membrane Presynaptic Endosome Membrane Alkenylglycerophosphocholine Hydrolase Activity Water Transport Golgi Apparatus Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lipid Metabolic Process Cellular Response To Mercury Ion Ascorbate Homeostasis ER To Golgi Transport Vesicle Membrane Endomembrane System Lysosome Organelle Fusion Fluid Transport Vesicle Fusion SNARE Binding Carbohydrate Binding Transmembrane Monodehydroascorbate Reductase Activity Membrane Destabilizing Activity Compact Myelin Transmembrane Ascorbate Ferrireductase Activity Respiratory Burst After Phagocytosis Organelle Membrane Fusion Monoatomic Ion Transport Sterol Biosynthetic Process Renal Water Homeostasis Metal Ion Transport Negative Regulation Of Lipoprotein Metabolic Process Water Transmembrane Transporter Activity Late Endosome Membrane Leukotriene-C4 Synthase Activity Membrane Fusion
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