XRCC1 and APLF

Number of citations of the paper that reports this interaction (PMID 17353262)
36

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		XRCC1	APLF
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 1	aprataxin and PNKP like factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Protein Binding Enzyme Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair	Single Strand Break Repair DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APEX1 APLF APTX BRCA1 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 SUMO1	9 interactors: APP FBXO25 GMCL1 IRX5 LIG4 PARP1 XRCC1 XRCC4 XRCC5
Entrez ID		7515	200558
HPRD ID		01909	09848
Ensembl ID		ENSG00000073050	ENSG00000169621
Uniprot IDs		B2RCY5 P18887 Q59HH7	Q8IW19
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC	2KQB 2KQC 2KQD 2KQE 2KUO
Enriched GO Terms of Interacting Partners?		DNA Repair Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair DNA Catabolic Process Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stress DNA-dependent DNA Replication DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis Response To Stimulus Response To Oxidative Stress DNA Catabolic Process, Endonucleolytic Aromatic Compound Catabolic Process Polynucleotide 3' Dephosphorylation Cellular Macromolecule Catabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Response To Inorganic Substance DNA Damage Response, Detection Of DNA Damage DNA Recombination Telomere Maintenance Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization DNA Ligation Regulation Of Nitrogen Compound Metabolic Process DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Catabolic Process Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Single Strand Break Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Protein ADP-ribosylation Cell Cycle Metabolic Process	Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Double-strand Break Repair DNA Repair Pro-B Cell Differentiation Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Response To DNA Damage Stimulus Lymphoid Progenitor Cell Differentiation DNA Ligation Response To Radiation Response To Ionizing Radiation Cellular Response To Lithium Ion DNA Metabolic Process Single Strand Break Repair Hematopoietic Progenitor Cell Differentiation Cell Differentiation Isotype Switching V(D)J Recombination Hemopoiesis Neuron Maturation Response To Lithium Ion DNA Recombination Somatic Recombination Of Immunoglobulin Gene Segments Immune System Development Regulation Of Neurogenesis Somatic Diversification Of Immunoglobulins Cellular Response To Stress Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Generation Of Neurons B Cell Activation Involved In Immune Response Neurogenesis Response To Gamma Radiation Regulation Of Cell Development Neuron Apoptotic Process Leukocyte Differentiation Organ Development Immunoglobulin Production Nucleobase-containing Compound Metabolic Process Base-excision Repair Positive Regulation Of Fibroblast Proliferation Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Intersection) ?