XRCC1 and OGG1

Number of citations of the paper that reports this interaction (PubMedID 12933815)
0

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		XRCC1	OGG1
Description		X-ray repair cross complementing 1	8-oxoguanine DNA glycosylase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex
	Molecular Function	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Catalytic Activity Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity Enzyme Binding Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Regulation Of DNA-templated Transcription DNA Damage Response Response To Oxidative Stress Response To Radiation Cellular Response To Reactive Oxygen Species Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Depurination Depyrimidination Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		21 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 TOPORS UBE2I UHRF2	7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1
Entrez ID		7515	4968
HPRD ID		01909	03582
Ensembl ID		ENSG00000073050	ENSG00000114026
Uniprot IDs		B2RCY5 P18887 Q59HH7	A0A9L9PXU1 E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2	1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13 7AYY 8VWT 8VWV 8VX4 8VX6 9EOZ
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process	Checkpoint Clamp Complex Cellular Response To Ionizing Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity Meiotic Cell Cycle Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition DNA Metabolic Process DNA Damage Response Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Enzyme Binding Oxidized DNA Binding Regulation Of Cell Cycle Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Nucleoplasm Telomere Maintenance Meiotic DNA Integrity Checkpoint Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Protein ADP-ribosylation Telomere Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Sodium Ion Import Across Plasma Membrane Protein Kinase C Signaling ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Regulation Of Base-excision Repair Positive Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stress Regulation Of Angiotensin-activated Signaling Pathway Sodium Ion Transport Regulation Of Cell Cycle Process
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