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XRCC1 and LIG3
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(biochemical)
HPRD
(two hybrid, in vivo)
XRCC1
LIG3
Description
X-ray repair cross complementing 1
DNA ligase 3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
ERCC4-ERCC1 Complex
Site Of DNA Damage
Nucleus
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
DNA Ligase III-XRCC1 Complex
Molecular Function
Damaged DNA Binding
Protein Binding
Enzyme Binding
Oxidized DNA Binding
Poly-ADP-D-ribose Binding
ADP-D-ribose Modification-dependent Protein Binding
3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
Nucleotide Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Ligase Activity
Metal Ion Binding
Biological Process
Single Strand Break Repair
DNA Repair
Base-excision Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Damage Response
Negative Regulation Of Protein ADP-ribosylation
Hippocampus Development
Response To Hydroperoxide
Telomeric DNA-containing Double Minutes Formation
Regulation Of Base-excision Repair
Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Lagging Strand Elongation
DNA Repair
Base-excision Repair
Base-excision Repair, Gap-filling
Double-strand Break Repair
DNA Recombination
DNA Damage Response
Mitochondrion Organization
V(D)J Recombination
Mitochondrial DNA Repair
Negative Regulation Of DNA Metabolic Process
Cell Division
DNA Biosynthetic Process
Negative Regulation Of Mitochondrial DNA Replication
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Bleomycin
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Height (
31562340
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Plasma amyloid beta peptide concentrations (ABx-42) (
24535457
)
Acute post-radiotherapy pain in breast cancer (
31196165
)
Electrocardiographic traits (multivariate) (
32602732
)
Night sleep phenotypes (
27126917
)
Nonobstructive coronary artery disease (
26534935
)
Pulse pressure (
30224653
)
QT interval (
19305408
24952745
29874175
30679814
)
TPE interval (resting) (
32386560
)
Interacting Genes
21 interacting genes:
ANXA1
APEX1
APLF
APTX
BRCA1
BTRC
CHEK2
CSNK2A1
CSNK2A2
LIG3
NEIL1
OGG1
PARP1
PARP2
PCNA
PNKP
POLB
RNF146
TOPORS
UBE2I
UHRF2
8 interacting genes:
APP
JTB
MALAT1
PARP1
TDP1
XRCC1
XRCC5
XRCC6
Entrez ID
7515
3980
HPRD ID
01909
02966
Ensembl ID
ENSG00000073050
ENSG00000005156
Uniprot IDs
B2RCY5
P18887
Q59HH7
B7Z6I3
P49916
PDB IDs
1CDZ
1XNA
1XNT
2D8M
2W3O
3K75
3K77
3LQC
5E6Q
5W7X
5W7Y
6WH1
6WH2
1IMO
1IN1
1UW0
3L2P
3PC7
3PC8
3QVG
6WH1
Enriched GO Terms of Interacting Partners
?
Damaged DNA Binding
DNA Repair
DNA Damage Response
DNA Metabolic Process
Base-excision Repair, Gap-filling
Nucleoplasm
Double-strand Break Repair
Macromolecule Metabolic Process
Cellular Response To Stress
Base-excision Repair
Nucleic Acid Metabolic Process
Nucleus
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Nucleobase-containing Compound Metabolic Process
Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
DNA Modification
Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Poly-ADP-D-ribose Binding
Catalytic Activity
Regulation Of DNA Metabolic Process
Transferase Activity
Regulation Of DNA Repair
Post-translational Protein Modification
DNA Recombination
Response To Radiation
NAD+-protein-serine ADP-ribosyltransferase Activity
Polynucleotide 3'-phosphatase Activity
SUMO Transferase Activity
DNA Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair-dependent Chromatin Remodeling
DNA ADP-ribosylation
NAD DNA ADP-ribosyltransferase Activity
Protein Kinase CK2 Complex
Response To Oxidative Stress
Chromatin Organization
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
Protein Localization To Chromosome
PML Body
Chromatin Remodeling
Protein Modification Process
Chromosome
Protein Modification By Small Protein Conjugation
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Double-strand Break Repair
Damaged DNA Binding
Telomere Maintenance
Telomere Organization
DNA End Binding
Ku70:Ku80 Complex
Protein-DNA Complex
Site Of DNA Damage
Chromosome, Telomeric Region
Regulation Of Base-excision Repair
DNA Repair
Response To Gamma Radiation
Regulation Of Phosphorus Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
DNA-dependent Protein Kinase Complex
DNA Recombination
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
5'-deoxyribose-5-phosphate Lyase Activity
Nonhomologous End Joining Complex
DNA Metabolic Process
Positive Regulation Of Phosphate Metabolic Process
Nuclear Telomere Cap Complex
Double-stranded Telomeric DNA Binding
DNA Damage Response
Chromosome Organization
Single Strand Break Repair
Regulation Of Telomere Maintenance
Positive Regulation Of Protein Kinase Activity
Double-stranded DNA Binding
Negative Regulation Of DNA Metabolic Process
Response To Radiation
Positive Regulation Of Kinase Activity
Regulation Of Innate Immune Response
Recombinational Repair
Response To Ionizing Radiation
Cellular Response To Radiation
Telomeric DNA Binding
Regulation Of Catalytic Activity
Cellular Response To Gamma Radiation
ATP-dependent Activity, Acting On DNA
Innate Immune Response
Negative Regulation Of Telomere Maintenance
DNA Helicase Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Chromosome
Regulation Of Chromosome Organization
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Phosphorylation
Regulation Of Kinase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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