XRCC1 and PARP2

Number of citations of the paper that reports this interaction (PMID 11948190)
133

Data Source:
HPRD (in vivo, in vitro)

		XRCC1	PARP2
Gene Name		X-ray repair complementing defective repair in Chinese hamster cells 1	poly (ADP-ribose) polymerase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Damaged DNA Binding Protein Binding Enzyme Binding	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair	DNA Repair Base-excision Repair Protein ADP-ribosylation Extrinsic Apoptotic Signaling Pathway
Pathways		Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APEX1 APLF APTX BRCA1 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 SUMO1	6 interactors: BUB3 CASP8 CENPA CENPB PARP1 XRCC1
Entrez ID		7515	10038
HPRD ID		01909	09660
Ensembl ID		ENSG00000073050	ENSG00000129484
Uniprot IDs		B2RCY5 P18887 Q59HH7	Q9UGN5
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC	3KCZ 3KJD
Enriched GO Terms of Interacting Partners?		DNA Repair Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair DNA Catabolic Process Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stress DNA-dependent DNA Replication DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis Response To Stimulus Response To Oxidative Stress DNA Catabolic Process, Endonucleolytic Aromatic Compound Catabolic Process Polynucleotide 3' Dephosphorylation Cellular Macromolecule Catabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Response To Inorganic Substance DNA Damage Response, Detection Of DNA Damage DNA Recombination Telomere Maintenance Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization DNA Ligation Regulation Of Nitrogen Compound Metabolic Process DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Catabolic Process Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Single Strand Break Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Protein ADP-ribosylation Cell Cycle Metabolic Process	Macrophage Differentiation Base-excision Repair Myeloid Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Growth Rate Protein Poly-ADP-ribosylation TRAIL-activated Apoptotic Signaling Pathway
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp1 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 tnks2 valuable
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp1 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 tnks2 valuable
Tagcloud (Intersection) ?