IL17RD and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		IL17RD	LTB4R2
Description		interleukin 17 receptor D	leukotriene B4 receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane	Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding Interleukin-17 Receptor Activity	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Negative Regulation Of Epithelial To Mesenchymal Transition Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways		MAP2K and MAPK activation	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 31562340)	Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		3 interacting genes: FGFR1 LTB4R2 MAP3K7	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		54756	56413
HPRD ID		08431	16153
Ensembl ID		ENSG00000144730	ENSG00000213906
Uniprot IDs		B4DXM5 Q8NFM7	B4E292 Q9NPC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Protein Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Kinase Activity Vitamin D3 Metabolic Process Positive Regulation Of Phosphate Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Receptor-receptor Interaction Positive Regulation Of Protein Phosphorylation Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Phosphorylation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Cementum Mineralization Diphosphate Metabolic Process Fibroblast Growth Factor Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling MAPK Cascade Cellular Response To Growth Factor Stimulus Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase Activity Regulation Of Kinase Activity Forebrain Neuroblast Division Regulation Of Lateral Mesodermal Cell Fate Specification Forebrain Ventricular Zone Progenitor Cell Division I-kappaB Phosphorylation Interleukin-17A-mediated Signaling Pathway Linear Polyubiquitin Binding MAP Kinase Kinase Kinase Kinase Activity Histone Kinase Activity Leukotriene Signaling Pathway Keratinocyte Migration Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Cell Cycle Protein Phosphorylation Auditory Receptor Cell Development Positive Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Cytokine Production Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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