SGPL1 and DDX21

		SGPL1	DDX21
Description		sphingosine-1-phosphate lyase 1	DExD-box helicase 21
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane B-WICH Complex
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding RNA Polymerase Inhibitor Activity
	Biological Process	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Osteoblast Differentiation Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Chromatin Remodeling RRNA Processing Transcription By RNA Polymerase II Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Defense Response To Virus R-loop Processing
Pathways		Sphingolipid catabolism	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Depression (quantitative trait) ( 20800221)
Interacting Genes		34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50	88 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN RBFOX2 RPL34 SUMO2 TERF1 TERF2 UBE2I USP7
Entrez ID		8879	9188
HPRD ID		07224	05895
Ensembl ID		ENSG00000166224	ENSG00000165732
Uniprot IDs		A0A8V8TN35 O95470	A0A8I5KYZ4 Q9NR30
PDB IDs		4Q6R 8AYF	2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?		Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling
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