BIK and BNIP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, genetic interference)

		BIK	BNIP3
Description		BCL2 interacting killer	BCL2 interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Postsynaptic Density Membrane Dendrite Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding Endoplasmic Reticulum-autophagosome Adaptor Activity Mitochondrion Autophagosome Adaptor Activity
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Apoptotic Process Response To Bacterium Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Cerebral Cortex Development Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Response To Axon Injury Oligodendrocyte Differentiation Brown Fat Cell Differentiation Neuron Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Defense Response To Virus Response To Hyperoxia Reticulophagy Substrate Localization To Autophagosome Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxygen-glucose Deprivation Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Granzyme-mediated Programmed Cell Death Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 21743057 25939597) Prostate cancer (SNP x SNP interaction) ( 22219177)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolite levels ( 23823483)
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	71 interacting genes: AGTR1 AMIGO1 ARL13B BCL2 BCL2L1 BCL2L2 BIK BNIP2 BNIP3L CD3E CD47 CLDN9 CLEC7A CLN8 CMTM5 CREB3 CREB3L1 EBAG9 EBP ELOVL4 ERGIC3 FAM209A FAM241B FATE1 FBXL4 FFAR2 FXYD6-FXYD2 GPR152 GPR37 GPR42 HIF1A HIVEP1 HPN HTR2B IFNGR2 JAGN1 KTN1 LDLRAD1 LMNA MALL MAP1LC3B MS4A3 NCBP1 OPA1 PLP2 PPTC7 REEP2 RHEB RNASEK RNF24 RPRM SCN3B SEC22A SEC23A SLC31A2 SLC35B1 SLC6A17 SLC71A2 SMIM3 SPACA1 TGM2 TLCD4 TM4SF18 TMEM101 TMEM106C TMEM11 TMEM205 TMPRSS2 TMX2 TNMD ZDHHC15
Entrez ID		638	664
HPRD ID		04547	04482
Ensembl ID		ENSG00000100290	ENSG00000176171
Uniprot IDs		Q13323	Q12983 Q6NVY4
PDB IDs			2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bcl-2 Family Protein Complex Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Mitochondrial Membrane Mitochondrion Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Release Of Cytochrome C From Mitochondria Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Golgi Membrane Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Apoptotic Process Membrane Organization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Programmed Cell Death Cell Death Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Ceramide Binding Transmembrane Transport Chemical Homeostasis Mitochondrion
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