BIK and PEX16

Number of citations: 82 (PubMedID 36949045)
Data Source: BioGRID (two hybrid)

		BIK	PEX16
Name		BCL2 interacting killer	peroxisomal biogenesis factor 16
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix Protein To Membrane Docking ER-dependent Peroxisome Organization Protein Import Into Peroxisome Membrane ER-dependent Peroxisome Localization
Pathways		None	Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Diseases		None	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Prostate cancer ( 21743057 25939597 ) Prostate cancer (SNP x SNP interaction) ( 22219177 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Axial length ( 24144296 ) SAPHO syndrome ( 33816493 )
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	35 interacting genes: AQP6 BDKRB2 BIK CD79A CLEC10A CREB3L1 CYB5R3 DEXI EBAG9 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FKBP7 GPR152 KCNJ6 LEPROTL1 MMGT1 PDZK1IP1 PEX19 PEX3 PGRMC2 REEP4 SAR1A SLC10A1 SLC10A6 SLC18A1 SLC35H1 SLC71A2 TIMMDC1 TMX2 TNFRSF17 UBC ZDHHC15
Entrez ID		638	9409
HPRD ID		04547	04526
Ensembl ID		ENSG00000100290	ENSG00000121680
Uniprot IDs		Q13323	E9PP98 Q9Y5Y5
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Protein Import Into Peroxisome Membrane Protein Binding Serotonin Transport Adaptive Immune Response Organic Hydroxy Compound Transport Mitochondrial Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Bile Acid And Bile Salt Transport