BIK and VTI1B

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		BIK	VTI1B
Description		BCL2 interacting killer	vesicle transport through interaction with t-SNAREs 1B
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Presynaptic Endosome Membrane
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Prostate cancer ( 21743057 25939597) Prostate cancer (SNP x SNP interaction) ( 22219177)	Blood protein levels ( 30072576)
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	38 interacting genes: AQP6 ASGR2 BIK CD46 CD79A CFTR CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SAR1A SLC16A7 SLC18A1 SLC35H1 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59
Entrez ID		638	10490
HPRD ID		04547	04440
Ensembl ID		ENSG00000100290	ENSG00000100568
Uniprot IDs		Q13323	Q9UEU0
PDB IDs			2V8S
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Membrane Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering SNAP Receptor Activity Membrane Docking SNARE Complex SNARE Binding Vesicle-mediated Transport Endomembrane System Vesicle Fusion Organelle Membrane Fusion Organelle Localization Membrane Organization Organelle Fusion Membrane Fusion Vesicle Organization Cornified Envelope Assembly Intracellular Protein Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Membrane Assembly Positive Regulation Of Immune Effector Process SNARE Complex Assembly Endoplasmic Reticulum Membrane Regulation Of Insulin Secretion Regulation Of Protein Localization Regulation Of Peptide Hormone Secretion Regulation Of Cellular Localization Positive Regulation Of Exocytosis Exocytosis Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Nuclear Envelope Organization Protein Binding Water Transport Endoplasmic Reticulum Regulation Of Adaptive Immune Response Neurotransmitter Transport Schaffer Collateral - CA1 Synapse Establishment Of Localization In Cell Nitrate Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Protein Transport Presynaptic Active Zone Membrane High-affinity IgG Receptor Activity Inhibitory MHC Class Ib Receptor Activity
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