BIK

Gene Name		BCL2-interacting killer (apoptosis-inducing)
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Gene Ontology Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Apoptotic Process Spermatogenesis Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Homooligomerization Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 21743057)
Protein-protein Interactions		11 interactors: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CRKL FATE1 MCL1 NR2F2 SOCS3 TANK
Entrez ID		638
HPRD ID		04547
Ensembl ID		ENSG00000100290
Uniprot IDs		Q13323
PDB IDs		2IPE
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Anoikis Intracellular Signal Transduction Apoptotic Signaling Pathway Response To Stress Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Signaling Negative Regulation Of Programmed Cell Death Cell Communication Apoptotic Process Reproductive Structure Development Negative Regulation Of Cell Death Reproductive System Development Intracellular Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Signal Transduction Neuron Apoptotic Process Death Negative Regulation Of Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Signaling Apoptotic Mitochondrial Changes Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Reproductive Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Sexual Reproduction Innate Immune Response Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stimulus
Tagcloud ?		abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl