BIK and TMEM14B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BIK	TMEM14B
Description		BCL2 interacting killer	transmembrane protein 14B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Heme Biosynthetic Process Nervous System Development Cerebral Cortex Development Neural Precursor Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 21743057 25939597) Prostate cancer (SNP x SNP interaction) ( 22219177)	Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	235 interacting genes: ABHD16A ABHD5 ACSL5 ADAM33 AGPAT3 AGPAT4 AGR3 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARL8B ARV1 ATP13A1 B4GALT7 BIK BLCAP BMP10 BSG BTN2A2 C10orf67 C14orf180 C1GALT1 C2CD2L CCL4 CD79A CEPT1 CFHR5 CIDEB CLDN10 CLDND2 CMTM5 CMTM8 CNIH2 CNIH3 CNIH4 COMT CPLX4 CREB3 CREB3L1 CXCL16 CYB561 CYB5R3 DEFB103A DEFB103B DGAT2L6 DHRSX EBP EI24 EMC6 EPHX4 ERGIC3 EXTL1 FA2H FADS6 FAM209A FCER1G FHL3 FIS1 FKBP8 FUNDC2 FXYD6-FXYD2 GDAP1 GIMAP1 GPR152 GPX8 GYPA GYPC HEXB HIBADH HIGD1C HMOX1 HMOX2 HSD17B11 HSD17B13 HSD3B1 IER3IP1 IFITM3 INSIG2 ITGAM JAGN1 KCNA1 KCNK1 KHDRBS2 LEPROTL1 LMNA LPAR3 LRCH1 MAL2 MARCHF5 MEOX2 MFSD12 MGAM MID2 MMD2 MS4A13 MS4A4A NAT8 NCALD NDUFA3 NEU1 NINJ1 NINJ2 NIPAL3 ORMDL1 OTULINL PAGE1 PDPN PDZK1IP1 PEX11G PIGF PLLP PLP1 PLP2 PMP22 PNLIPRP1 PPP2R3B PRAF2 PRH1 PRTFDC1 PSMD3 PTPMT1 RABAC1 REEP4 RHD RHOT2 SAR1B SCAMP5 SCN3B SCRG1 SERF1A SERF1B SERP1 SERP2 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SLC10A6 SLC16A10 SLC16A13 SLC18A1 SLC19A3 SLC2A6 SLC30A3 SLC30A8 SLC35A4 SLC35E3 SLC35E4 SLC35F1 SLC35F6 SLC35G1 SLC35H1 SLC39A2 SLC39A7 SLC48A1 SLC61A1 SLC7A8 SMAGP SMPD2 SPRY2 SQLE ST6GAL2 STOM STX12 STX3 STX6 STX8 SUCNR1 SYNGR1 SYNJ2BP TAP1 TAS2R19 TBC1D20 TEX44 THBD TIMM22 TIMM23 TIMMDC1 TLCD1 TM4SF4 TMEM11 TMEM120A TMEM120B TMEM121 TMEM147 TMEM14A TMEM14C TMEM187 TMEM19 TMEM203 TMEM220 TMEM222 TMEM229B TMEM243 TMEM254 TMEM255B TMEM267 TMEM42 TMEM50A TMEM50B TMEM51 TMEM60 TMEM69 TMEM97 TMIE TMUB1 TMX2 TOMM6 TSPAN2 TSPO TVP23B UBE2J1 UBE2J2 UBE3A UBIAD1 UBXN8 UNC50 UNC93A VAMP1 VAMP5 VMA12 VRK2 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC11 ZDHHC22 ZDHHC24 ZFPL1
Entrez ID		638	81853
HPRD ID		04547	15523
Ensembl ID		ENSG00000100290	ENSG00000137210
Uniprot IDs		Q13323	A0A087WU83 C9JCY4 C9JQS0 Q9NUH8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Endomembrane System Golgi Apparatus Lipid Biosynthetic Process Membrane Organization Cellular Localization Transmembrane Transport Golgi Membrane Mitochondrial Outer Membrane Transmembrane Transporter Activity Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Establishment Of Protein Localization Serine Import Into Mitochondrion Organic Cation Transport SNARE Complex Structural Constituent Of Myelin Sheath Mitochondrial Membrane SNAP Receptor Activity Organelle Fusion Monoatomic Ion Transmembrane Transporter Activity Steroid Biosynthetic Process Amino Acid Transport Myelination Axon Ensheathment Vesicle Fusion Organic Hydroxy Compound Transport Organelle Membrane Fusion Lipid Homeostasis Heme Metabolic Process Pigment Metabolic Process Cholesterol Biosynthetic Process Golgi Trans Cisterna Import Into The Mitochondrion COPII-coated ER To Golgi Transport Vesicle Lipid Metabolic Process Heme Oxidation Heme Oxygenase (decyclizing) Activity Amino Acid Transmembrane Transport Golgi Medial Cisterna SNARE Binding Zinc Ion Transmembrane Transporter Activity Sterol Biosynthetic Process Serine Transport Porphyrin-containing Compound Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Chemical Homeostasis
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