BIK and ASB11

Number of citations of the paper that reports this interaction (PubMedID 31387940)
57

Data Source:
BioGRID (enzymatic study)

		BIK	ASB11
Description		BCL2 interacting killer	ankyrin repeat and SOCS box containing 11
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Endoplasmic Reticulum Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Prostate cancer ( 21743057 25939597) Prostate cancer (SNP x SNP interaction) ( 22219177)	vascular endothelial growth factor D levels ( 25147954)
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	7 interacting genes: BIK CUL5 ELOB ELOC PAICS RNF7 UBC
Entrez ID		638	140456
HPRD ID		04547	06450
Ensembl ID		ENSG00000100290	ENSG00000165192
Uniprot IDs		Q13323	Q8WXH4
PDB IDs			4UUC
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Cul5-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Focal Adhesion Disassembly Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway MiRNA Catabolic Process Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Macromolecule Catabolic Process Negative Regulation Of MiRNA-mediated Gene Silencing Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul2-RING Ubiquitin Ligase Complex Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Modification-dependent Protein Catabolic Process MiRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein Modification Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Neuron Migration Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly DNA-templated Transcription Initiation Regulation Of Cell-substrate Junction Organization Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Epithelial To Mesenchymal Transition Proteolysis Mesenchymal Cell Differentiation Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Junction Assembly Symbiont-mediated Suppression Of Host Innate Immune Response
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