BIK and GOSR2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		BIK	GOSR2
Description		BCL2 interacting killer	golgi SNAP receptor complex member 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endomembrane System Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport
Pathways			COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic
Drugs
Diseases
GWAS		Prostate cancer ( 21743057 25939597) Prostate cancer (SNP x SNP interaction) ( 22219177)	Aortic root size ( 28394258) Aortic valve area ( 33125279) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Congenital heart disease (anomalies of thoracic arteries and veins) ( 33201861) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Pulse pressure ( 28739976 27841878 30578418) QRS duration ( 27577874 21076409 30012220) QT interval ( 29874175) Systolic blood pressure ( 30578418 27618447 28739976 27618452 28135244 21909115 27841878)
Interacting Genes		116 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ARLN ASB11 ATP13A1 BCL2 BCL2A1 BCL2L1 BCL2L2 BET1 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 CD53 CD72 CDS2 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB561D2 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A FKBP8 GOSR2 GPX8 GRM2 HMOX2 IGFBP5 INSIG2 KCNN4 LNPEP MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM ORMDL1 ORMDL2 PBX3 PEX16 PGAP2 PGRMC1 PLLP PLN PLP1 PLP2 PLPP4 PMP22 REEP4 REEP6 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 SYNGR1 TANK TMBIM1 TMEM107 TMEM11 TMEM147 TMEM14B TMEM14C TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 UPK1B VAMP3 VAMP4 VAMP5 VAPA VAPB VMA12 VTI1B YIPF4 ZFPL1	53 interacting genes: APP AQP6 ARF1 ARL13B BIK BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SLC35H1 SLC61A1 SLC71A2 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1
Entrez ID		638	9570
HPRD ID		04547	04937
Ensembl ID		ENSG00000100290	ENSG00000108433
Uniprot IDs		Q13323	A0A1W2PPP5 A0A1W2PQ77 A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRC2 A0A1W2PRL0 I3NI02 O14653
PDB IDs			3EG9
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Organelle Fusion Protein Binding Membrane Organization Mitochondrial Outer Membrane SNAP Receptor Activity Bcl-2 Family Protein Complex Release Of Cytochrome C From Mitochondria SNARE Complex Vesicle-mediated Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Fusion Vesicle Organization Endomembrane System Regulation Of Cellular Localization Golgi Vesicle Transport Chemical Homeostasis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Vesicle Fusion BH3 Domain Binding Apoptotic Mitochondrial Changes Organelle Membrane Fusion Cellular Homeostasis Channel Activity Vesicle Fusion With Golgi Apparatus Intracellular Chemical Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Docking Pigment Metabolic Process Presynaptic Endosome Membrane Intracellular Monoatomic Cation Homeostasis Response To Cytokine Heme Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Intracellular Monoatomic Ion Homeostasis Response To Peptide Regulation Of Transport Homeostatic Process Inorganic Ion Homeostasis Dendritic Cell Apoptotic Process Ascorbate Homeostasis FFAT Motif Binding Oxysterol Binding Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Localization	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ascorbate Homeostasis Positive Regulation Of Protein Localization To Cell Surface Transmembrane Monodehydroascorbate Reductase Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex SNARE Binding Vesicle Docking Bile Acid:sodium Symporter Activity Organelle Localization By Membrane Tethering Membrane Fusion Regulation Of Toll Signaling Pathway Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Membrane Docking SNAP Receptor Activity Protein Binding Fatty Acid Elongation, Saturated Fatty Acid Vesicle Fusion Regulation Of Protein Localization To Cell Surface Organelle Membrane Fusion Meiotic Nuclear Membrane Microtubule Tethering Complex SNARE Complex Regulation Of Synaptic Vesicle Priming SNARE Complex Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acetylcholine Receptor Binding Very Long-chain Fatty Acid Biosynthetic Process Organelle Fusion Fatty Acid Elongation Endoplasmic Reticulum Organization
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