INPP1 and SYCE3

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		INPP1	SYCE3
Description		inositol polyphosphate-1-phosphatase	synaptonemal complex central element protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Central Element Nucleus Chromosome
	Molecular Function	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Inositol-1,3,4-trisphosphate 1-phosphatase Activity	Protein Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process	Apoptotic Process Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Spermatogenesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Developmental Process Cell Division Meiotic Cell Cycle Positive Regulation Of Reproductive Process
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	Meiotic synapsis
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Lung cancer (SNP x SNP interaction) ( 24325914) Machado-Joseph disease (age at onset) ( 32205469)	Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		11 interacting genes: BBLN BRCA1 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1	7 interacting genes: BLOC1S6 HAUS1 INPP1 KRT79 PKN1 SGF29 TRIM54
Entrez ID		3628	644186
HPRD ID		00923
Ensembl ID		ENSG00000151689	ENSG00000217442
Uniprot IDs		P49441 Q6IBG4	A1L190
PDB IDs			6H86
Enriched GO Terms of Interacting Partners?		DNA Strand Resection Involved In Replication Fork Processing Histone H2AK127 Ubiquitin Ligase Activity DNA Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity Homologous Recombination Cellular Response To Tumor Necrosis Factor Chromosome BRCA1-BARD1 Complex DNA Recombination Okazaki Fragment Processing Involved In Mitotic DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Astrocyte Activation Circadian Temperature Homeostasis Positive Regulation Of Bile Acid Biosynthetic Process G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Subapical Part Of Cell Multinuclear Osteoclast Differentiation BRCA1-B Complex Cell Division Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Type 5 Metabotropic Glutamate Receptor Binding Response To Tumor Necrosis Factor	Inositol-1,3,4-trisphosphate 1-phosphatase Activity Inositol-1,4-bisphosphate 1-phosphatase Activity Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle
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