INPP1 and NDC80

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		INPP1	NDC80
Gene Name		inositol polyphosphate-1-phosphatase	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Inositol-1,4-bisphosphate 1-phosphatase Activity Metal Ion Binding Inositol-1,3,4-trisphosphate 1-phosphatase Activity	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Signal Transduction Dephosphorylation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BRCA1 C9orf16 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		3628	10403
HPRD ID		00923	06277
Ensembl ID		ENSG00000151689	ENSG00000080986
Uniprot IDs		P49441 Q6IBG4	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Cell Cycle Chromosome Segregation DNA Recombination Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Bile Acid Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Division Circadian Temperature Homeostasis Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Lipid Biosynthetic Process Double-strand Break Repair Otolith Morphogenesis Attachment Of Mitotic Spindle Microtubules To Kinetochore Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Negative Regulation Of Receptor Biosynthetic Process Lagging Strand Elongation Somite Specification Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Microtubule-based Process Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Otolith Development Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Involved In DNA Repair Regulation Of Histone H3-K9 Acetylation Organelle Organization Cellular Nitrogen Compound Metabolic Process Attachment Of Spindle Microtubules To Kinetochore DNA Replication Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation DNA Ligation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?			assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?			assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?