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INPP1 and LIG1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
INPP1
LIG1
Gene Name
inositol polyphosphate-1-phosphatase
ligase I, DNA, ATP-dependent
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Nucleoplasm
Chromosome
Mitochondrion
Golgi Apparatus
Intracellular Membrane-bounded Organelle
Molecular Function
Inositol-1,4-bisphosphate 1-phosphatase Activity
Metal Ion Binding
Inositol-1,3,4-trisphosphate 1-phosphatase Activity
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
ATP Binding
Metal Ion Binding
Biological Process
Phosphate-containing Compound Metabolic Process
Signal Transduction
Dephosphorylation
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Phosphatidylinositol Phosphorylation
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Lagging Strand Elongation
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Anatomical Structure Morphogenesis
Telomere Maintenance Via Semi-conservative Replication
V(D)J Recombination
Response To Hydrogen Peroxide
DNA Ligation Involved In DNA Repair
Cell Division
DNA Biosynthetic Process
Pathways
Synthesis of IP2, IP, and Ins in the cytosol
Inositol phosphate metabolism
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Telomere Maintenance
Removal of DNA patch containing abasic residue
Homologous recombination repair of replication-independent double-strand breaks
Double-Strand Break Repair
Resolution of D-loop structures through Holliday junction intermediates
Resolution of Abasic Sites (AP sites)
Base Excision Repair
Resolution of D-loop structures
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the lagging strand
Processive synthesis on the C-strand of the telomere
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Homologous Recombination Repair
Drugs
Bleomycin
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
BRCA1
C9orf16
DYNLL1
LDOC1
LIG1
MEOX2
NDC80
NECAB2
NR1D1
SYCE3
USHBP1
6 interactors:
CSNK2A1
INPP1
MRE11A
PCNA
RGS2
TUBB3
Entrez ID
3628
3978
HPRD ID
00923
00534
Ensembl ID
ENSG00000151689
ENSG00000105486
Uniprot IDs
P49441
Q6IBG4
B4DTU4
F5GZ28
P18858
PDB IDs
1X9N
Enriched GO Terms of Interacting Partners
?
Cell Cycle Process
Cell Cycle
Chromosome Segregation
DNA Recombination
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Bile Acid Biosynthetic Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Cell Division
Circadian Temperature Homeostasis
Positive Regulation Of Histone H3-K9 Acetylation
Regulation Of Type B Pancreatic Cell Proliferation
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Regulation Of Lipid Biosynthetic Process
Double-strand Break Repair
Otolith Morphogenesis
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Cellular Response To Indole-3-methanol
Negative Regulation Of Centriole Replication
Negative Regulation Of Receptor Biosynthetic Process
Lagging Strand Elongation
Somite Specification
Intrinsic Apoptotic Signaling Pathway
Mitotic Cell Cycle
Microtubule-based Process
Nucleobase-containing Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Otolith Development
Dosage Compensation By Inactivation Of X Chromosome
Protein K6-linked Ubiquitination
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Histone H3-K9 Methylation
Positive Regulation Of Histone H3-K9 Methylation
Dosage Compensation
Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter
DNA Ligation Involved In DNA Repair
Regulation Of Histone H3-K9 Acetylation
Organelle Organization
Cellular Nitrogen Compound Metabolic Process
Attachment Of Spindle Microtubules To Kinetochore
DNA Replication
Regulation Of Centriole Replication
Positive Regulation Of Histone H3-K4 Methylation
DNA Ligation
Regulation Of Histone H4 Acetylation
Negative Regulation Of Fatty Acid Biosynthetic Process
Cell Cycle
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Telomere Maintenance Via Telomere Lengthening
Cell Cycle Process
Base-excision Repair
Telomere Maintenance
Nucleotide-excision Repair
Positive Regulation Of Deoxyribonuclease Activity
Regulation Of DNA Replication
Leading Strand Elongation
Mitotic Cell Cycle Checkpoint
Negative Regulation Of DNA Endoreduplication
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Catalytic Activity
Cell Cycle Checkpoint
Regulation Of Mitotic Recombination
Regulation Of Adrenergic Receptor Signaling Pathway
DNA Recombination
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of CAMP-mediated Signaling
Negative Regulation Of Phospholipase Activity
DNA Replication
Protein Folding
Intra-S DNA Damage Checkpoint
Relaxation Of Vascular Smooth Muscle
Regulation Of DNA Endoreduplication
Relaxation Of Smooth Muscle
Telomere Maintenance Via Telomerase
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Striated Muscle Contraction
Translesion Synthesis
Negative Regulation Of Muscle Hypertrophy
Positive Regulation Of Microtubule Polymerization
Relaxation Of Cardiac Muscle
Negative Regulation Of Smooth Muscle Contraction
Axon Guidance
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Hydrolase Activity
Nucleotide-excision Repair, DNA Gap Filling
Mitotic G2 DNA Damage Checkpoint
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Catalytic Activity
Cell Differentiation
Positive Regulation Of Metabolic Process
Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of Cell Cycle
Negative Regulation Of Lipase Activity
Postreplication Repair
Negative Regulation Of Muscle Contraction
Tagcloud
?
24h
300mum
513a
5p
abp
aminobiphenyl
array
arrays
arylamine
bioinformatic
carcinogen
comet
damage
deregulation
eventually
exo1
fancg
hepg2
mirna
mirnas
parallel
pcna
pcr
qrt
rad18
repair
ung
validated
xrcc2
Tagcloud (Difference)
?
24h
300mum
513a
5p
abp
aminobiphenyl
array
arrays
arylamine
bioinformatic
carcinogen
comet
damage
deregulation
eventually
exo1
fancg
hepg2
mirna
mirnas
parallel
pcna
pcr
qrt
rad18
repair
ung
validated
xrcc2
Tagcloud (Intersection)
?