INPP1 and BBLN

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid)

		INPP1	BBLN
Name		inositol polyphosphate-1-phosphatase	bublin coiled coil protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Kinetochore Microtubule Cytoskeleton Intermediate Filament Cell Junction Anchoring Junction Subapical Part Of Cell
	Molecular Function	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Inositol-1,3,4-trisphosphate 1-phosphatase Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process	Apoptotic Process Gene Expression Osteoclast Differentiation Intermediate Filament Bundle Assembly Bone Resorption Bone Development Multinuclear Osteoclast Differentiation Apoptotic Signaling Pathway
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	None
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Machado-Joseph disease (age at onset) ( 32205469 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: CIZ1 GOLGA2
Interacting Genes		11 interacting genes: BBLN BRCA1 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1	7 interacting genes: ATP6V1E2 CEP290 FGD4 IKBIP INPP1 KRT20 THAP11
Entrez ID		3628	79095
HPRD ID		00923	12946
Ensembl ID		ENSG00000151689	ENSG00000171159
Uniprot IDs		P49441 Q6IBG4	Q9BUW7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		DNA Strand Resection Involved In Replication Fork Processing Histone H2AK127 Ubiquitin Ligase Activity DNA Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity Homologous Recombination Cellular Response To Tumor Necrosis Factor Chromosome BRCA1-BARD1 Complex DNA Recombination Okazaki Fragment Processing Involved In Mitotic DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Negative Regulation Of Astrocyte Activation Circadian Temperature Homeostasis Positive Regulation Of Bile Acid Biosynthetic Process G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Subapical Part Of Cell Multinuclear Osteoclast Differentiation BRCA1-B Complex Cell Division Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Type 5 Metabotropic Glutamate Receptor Binding Response To Tumor Necrosis Factor	None