ETAA1 and ATR

Number of citations of the paper that reports this interaction (PubMedID 30940728)
31

Data Source:
BioGRID (pull down)

		ETAA1	ATR
Description		ETAA1 activator of ATR kinase	ATR checkpoint kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Replication Fork	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage
	Molecular Function	Protein Binding Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Repair DNA Damage Response Replication Fork Processing Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Checkpoint	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair
Pathways			Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs			Ceralasertib
Diseases			Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Endometriosis ( 28537267) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 27182965) Milk allergy ( 25710614) Pancreatic cancer ( 26098869) Periodontitis (CDC/AAP) ( 24024966) Photic sneeze reflex ( 27182965) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 28430825)	Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 28957414 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		2 interacting genes: ATR ATRIP	58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5
Entrez ID		54465	545
HPRD ID		13282	08369
Ensembl ID		ENSG00000143971	ENSG00000175054
Uniprot IDs		Q9NY74	Q13535
PDB IDs		8JZV	5YZ0
Enriched GO Terms of Interacting Partners?		ATR-ATRIP Complex Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Establishment Of RNA Localization To Telomere Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Positive Regulation Of Telomerase Catalytic Core Complex Assembly Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Histone H2AXS139 Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Negative Regulation Of Cell Cycle Process MutSalpha Complex Binding Negative Regulation Of Cell Cycle MutLalpha Complex Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Membrane Disassembly Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Nuclear Membrane Disassembly DNA Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Positive Regulation Of Telomere Maintenance Via Telomerase Nuclear Envelope Organization Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break K63-linked Polyubiquitin Modification-dependent Protein Binding Cellular Response To Gamma Radiation Viral Protein Processing Response To Arsenic-containing Substance DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Damage Response Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Interstrand Cross-link Repair Site Of DNA Damage Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Nuclear Membrane Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition
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