ETAA1

Description		ETAA1 activator of ATR kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Replication Fork
	Molecular Function	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Repair DNA Damage Response Replication Fork Processing Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Checkpoint
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Endometriosis ( 28537267) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 27182965) Milk allergy ( 25710614) Pancreatic cancer ( 26098869) Periodontitis (CDC/AAP) ( 24024966) Photic sneeze reflex ( 27182965) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 28430825)
Novel Interacting Genes		1 novel interacting genes: MOGS
Interacting Genes		2 interacting genes: ATR ATRIP
Entrez ID		54465
HPRD ID		13282
Ensembl ID		ENSG00000143971
Uniprot IDs		Q9NY74
PDB IDs		8JZV
Enriched GO Terms of Interacting Partners?		ATR-ATRIP Complex Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Establishment Of RNA Localization To Telomere Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Positive Regulation Of Telomerase Catalytic Core Complex Assembly Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Histone H2AXS139 Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Negative Regulation Of Cell Cycle Process MutSalpha Complex Binding Negative Regulation Of Cell Cycle MutLalpha Complex Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Membrane Disassembly Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Nuclear Membrane Disassembly DNA Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Positive Regulation Of Telomere Maintenance Via Telomerase Nuclear Envelope Organization Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break K63-linked Polyubiquitin Modification-dependent Protein Binding Cellular Response To Gamma Radiation Viral Protein Processing Response To Arsenic-containing Substance DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Damage Response Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Interstrand Cross-link Repair Site Of DNA Damage Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Nuclear Membrane Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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