PRR13 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRR13	KLHL12
Description		proline rich 13	kelch like family member 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process		Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways			Degradation of DVL
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		53 interacting genes: AP2M1 BAIAP2 CBLL2 CELF5 DAZAP2 DVL3 EWSR1 FAM133A FUBP1 FXR1 GPAA1 H2BC15 IL16 KHDC4 KLHL12 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP13-1 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP4-12 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LGALS3 LNX1 MSX2 NKX1-2 OTX1 PEX5 PLSCR1 PPIA PSMA3 PSME3 RBM47 RP9P RTN4 SDCBP SDCBP2 SMUG1 SREK1IP1 SRI TIAL1 TNFAIP8 TRIP13 VAC14 YPEL3 ZCCHC10	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		54458	59349
HPRD ID		13211	13925
Ensembl ID		ENSG00000205352	ENSG00000117153
Uniprot IDs		Q9NZ81	Q53G59 Q9H7R2
PDB IDs			2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytosol Keratin Filament Identical Protein Binding	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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