PRR13 and KLHL12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		PRR13	KLHL12
Gene Name		proline rich 13	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function		Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BAIAP2 EWSR1 FAM133A GPAA1 KLHL12 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP4-12 LGALS3 LNX1 PEX5 PLSCR1 PPIA PSMA3 PSME3 RP9P RTN4 SDCBP SDCBP2 SRI TNFAIP8 VAC14 ZCCHC10	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		54458	59349
HPRD ID		13211	13925
Ensembl ID		ENSG00000205352	ENSG00000117153
Uniprot IDs		F8VRX0 Q9NZ81	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Endomembrane System Organization Cell Migration Membrane Organization Cell Motility Negative Regulation Of Wnt Signaling Pathway Glycerophospholipid Biosynthetic Process Endoplasmic Reticulum Organization Apoptotic Process Response To Stimulus Viral Process Regulation Of Canonical Wnt Signaling Pathway Programmed Cell Death Phospholipid Biosynthetic Process Regulation Of Signaling Protein Ubiquitination Cell Death Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Protein Modification By Small Protein Conjugation Negative Regulation Of Immunological Synapse Formation Uncoating Of Virus Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cellular Localization Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Process Regulation Of Viral Genome Replication Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glycerophospholipid Metabolic Process Regulation Of Wnt Signaling Pathway Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Cellular Component Assembly Locomotion Positive Regulation Of Secretion Negative Regulation Of Protein Homotetramerization Intracellular Sequestering Of Iron Ion Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transport Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
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