AKR7A3

Gene Name		aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Aldo-keto Reductase (NADP) Activity Electron Carrier Activity
	Biological Process	Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: AKR7A2 TERF2IP
Entrez ID		22977
HPRD ID		07089
Ensembl ID
Uniprot IDs		O95154
PDB IDs		2CLP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Telomere Capping Daunorubicin Metabolic Process Doxorubicin Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Glycoside Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Quinone Metabolic Process Regulation Of DNA Repair Regulation Of DNA Recombination Cellular Aldehyde Metabolic Process Telomere Maintenance Cellular Ketone Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Response To DNA Damage Stimulus Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		abcb4 anabolic bioassay built carcinogenic carcinogenicity carcinogens ccng1 cdkn1a dataset datasets employs formally gates generalizable informative integrates mathematical methodologies nongenotoxic omics phlda3 rankings reproducible rodent signatures subsamplings toxicogenomics virtue