Wiki-Pi
About
Search
People
Updates
Search
POLR2A and CASP10
Number of citations of the paper that reports this interaction (PubMedID
9153302
)
66
Data Source:
HPRD
(in vitro, in vivo)
POLR2A
CASP10
Description
RNA polymerase II subunit A
caspase 10
Image
No pdb structure
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Prp19 Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Chromosome
Nucleolus
Cytoplasm
Cytoplasm
Cytosol
CD95 Death-inducing Signaling Complex
Ripoptosome
Molecular Function
Magnesium Ion Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
DNA-directed RNA Polymerase Activity
RNA-directed RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Nucleotidyltransferase Activity
Hydrolase Activity
Kinase Binding
Ubiquitin Protein Ligase Binding
5'-3' RNA Polymerase Activity
Metal Ion Binding
Microfibril Binding
Promoter-specific Chromatin Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Biological Process
RNA-templated Transcription
DNA-templated Transcription
DNA-templated Transcription Termination
Regulation Of DNA-templated Transcription
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Gene Expression
Positive Regulation Of RNA Splicing
MRNA Transcription By RNA Polymerase II
Proteolysis
Apoptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Protein Maturation
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
TP53 Regulates Transcription of Caspase Activators and Caspases
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Atrial fibrillation (
29892015
)
Brain morphology (MOSTest) (
32665545
)
Central corneal thickness (
29760442
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean platelet volume (
32888494
)
Myopia (
27182965
)
Parkinson's disease progression (cognitive) (
33958783
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Alanine aminotransferase levels (
33547301
)
Basal cell carcinoma (
25855136
)
Chronic lymphocytic leukemia (
23770605
28165464
)
Chronic lymphocytic leukemia or rheumatoid arthritis (
31407831
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
103 interacting genes:
ABL1
ACTB
ACTL6A
ATM
BARD1
BRCA1
CALCOCO1
CALCOCO2
CASP10
CCNH
CCNK
CCNL2
CCNT1
CDC14A
CDK12
CDK8
CDK9
CPSF1
CPSF2
CPSF3
CREBBP
CSH2
CSNK2A1
CSTF1
CSTF2
CTCF
CTDP1
CTDSP1
CTDSP2
DHX9
EIF4ENIF1
ELL
ERCC5
ERCC6
ERCC8
ERG
ESR1
FUS
GRB2
GTF2B
GTF2H4
H1-2
HNRNPF
HTATSF1
IFTAP
ITCH
IWS1
KAT2B
KLK2
KMT2D
LEO1
MCM3
MED21
MNAT1
MYH6
NEDD4
NONO
NR0B2
NSD1
OTUD5
PCIF1
PHF8
PIN1
POLR2C
POLR2D
POLR2E
POLR2F
POLR2G
POLR2H
POLR2L
PPIG
PPP1CA
PPP2CA
PQBP1
PRMT5
PRPF19
PTEN
RNF10
SAFB
SKP2
SMN1
SMN2
SMURF1
SNAR-B2
SND1
SUB1
SUMO2
SUPT5H
TAF10
TCEA1
TCERG1
TDRD3
TRAK1
TRAM2
TTK
U2AF2
UBE2L3
UPF1
VDR
XAB2
XRCC5
ZC3H4
ZNF74
30 interacting genes:
BFAR
BID
CASP1
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8
CASP8AP2
CASP9
CCAR1
CFLAR
DEDD
DEDD2
DSP
ECE2
FADD
NFKBIL1
OIP5
PHF20L1
POLR2A
PRDX6
RB1
RIOK3
RYBP
TNFRSF1A
TRAF1
XIAP
Entrez ID
5430
843
HPRD ID
08916
03458
Ensembl ID
ENSG00000181222
ENSG00000003400
Uniprot IDs
A0AAG2TJB2
P24928
A0A0S2Z3G5
A0A0S2Z3Z5
Q92851
PDB IDs
2GHQ
2GHT
2LTO
3D9K
3D9L
3D9M
3D9N
3D9O
3D9P
4JXT
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M3H
5M3J
6DRD
6F5P
6G0R
6IC8
6IC9
6O9L
6Q5Y
6XKB
6XRE
7EGB
7EGC
7LBM
7YCX
7Z1K
7Z42
8PM0
8PNP
8PNQ
8R3K
8R3L
8R60
8R65
9B9L
9EHZ
9EI1
9EI2
9EI3
9EI4
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleic Acid Metabolic Process
Nucleus
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
MRNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-templated Transcription Elongation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of DNA Metabolic Process
DNA Repair
Regulation Of Cell Cycle
Regulation Of DNA Repair
DNA Metabolic Process
Regulation Of DNA-templated Transcription Elongation
Positive Regulation Of Transcription Elongation By RNA Polymerase II
MRNA Processing
RNA Polymerase II, Core Complex
DNA Damage Response
Transcription Elongation By RNA Polymerase II
Chromatin Binding
Regulation Of Cell Cycle Process
RNA Polymerase Binding
Regulation Of Transcription Elongation By RNA Polymerase II
Chromatin Organization
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Cell Death
Programmed Cell Death
Apoptotic Process
Cysteine-type Endopeptidase Activity
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cysteine-type Peptidase Activity
Death Receptor Binding
Extrinsic Apoptotic Signaling Pathway
Protein Processing
Pyroptotic Inflammatory Response
Death-inducing Signaling Complex
Regulation Of Canonical NF-kappaB Signal Transduction
Execution Phase Of Apoptosis
Regulation Of Neuron Apoptotic Process
Neuron Apoptotic Process
Regulation Of Necroptotic Process
Cellular Response To Mechanical Stimulus
Protein Maturation
Regulation Of Programmed Necrotic Cell Death
Cell Surface Receptor Signaling Pathway
Peptidase Activity
Cellular Response To Staurosporine
Proteolysis
Epithelial Cell Apoptotic Process
Regulation Of Signal Transduction
Glial Cell Apoptotic Process
Positive Regulation Of Execution Phase Of Apoptosis
Response To Mechanical Stimulus
Response To Anesthetic
Ripoptosome
CD95 Death-inducing Signaling Complex
Response To Lipopolysaccharide
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Defense Response
Response To Molecule Of Bacterial Origin
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Response To Stress
Regulation Of Defense Response
Regulation Of Intracellular Signal Transduction
Response To Cobalt Ion
Regulation Of Apoptotic Signaling Pathway
Fibroblast Apoptotic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?